The role of thymidine kinase in cancer diseases

O Topolcan, L Holubec Jr - Expert opinion on medical diagnostics, 2008 - Taylor & Francis
Thymidine kinase 1 (TK 1-fetal) is a cell cycle-dependent marker that increases dramatically
during the S-phase of the cell cycle. In this review, the authors discuss serum levels of …

Thymidine kinase and cancer monitoring

S Aufderklamm, T Todenhöfer, G Gakis, S Kruck… - Cancer letters, 2012 - Elsevier
Thymidine kinases (TK) have a key function in the synthesis of DNA. Two isoenzymes have
been characterized: TK1 is cell cycle-dependent and present in the cytoplasm whereas TK2 …

Exploring the mechanism of curcumin in the treatment of colon cancer based on network pharmacology and molecular docking

Q He, C Liu, X Wang, K Rong, M Zhu, L Duan… - Frontiers in …, 2023 - frontiersin.org
Objective: Curcumin is a plant polyphenol extracted from the Chinese herb turmeric. It was
found that curcumin has good anti-cancer properties in a variety of cancers, but the exact …

Emerging biomarkers in bladder cancer identified by network analysis of transcriptomic data

M Giulietti, G Occhipinti, A Righetti, M Bracci… - Frontiers in …, 2018 - frontiersin.org
Bladder cancer is a very common malignancy. Although new treatment strategies have been
developed, the identification of new therapeutic targets and reliable diagnostic/prognostic …

The proliferation marker thymidine kinase 1 in clinical use

J Zhou, E He, S Skog - Molecular and clinical oncology, 2013 - spandidos-publications.com
Tumor-related biomarkers are used for the diagnosis, prognosis and monitoring of
treatments and follow-up of cancer patients, although only a few are fully accepted for the …

Serum thymidine kinase 1 correlates to clinical stages and clinical reactions and monitors the outcome of therapy of 1,247 cancer patients in routine clinical settings

Y Chen, M Ying, YS Chen, M Hu, Y Lin, D Chen… - International journal of …, 2010 - Springer
Background Thymidine kinase 1 in serum (STK1) has been found to be a reliable
proliferation marker in clinical trials. In this study, we examined the significance of STK1 in …

Serological thymidine kinase 1 is a biomarker for early detection of tumours—a health screening study on 35,365 people, using a sensitive chemiluminescent dot blot …

ZH Chen, SQ Huang, Y Wang, AZ Yang, J Wen, XH Xu… - Sensors, 2011 - mdpi.com
Serological thymidine kinase 1 (STK1) is a reliable proliferation marker for prognosis,
monitoring tumour therapy, and relapse. Here we investigated the use of STK1 in health …

[HTML][HTML] Concentration of human thymidine kinase 1 discover invisible malignant human tumours

J Zhou, H Li, C Fang, P Gao, C **, S Liu, R Zou… - European Journal of …, 2022 - Elsevier
Early discover of risk progression of invisible carcinomas is important for a prerequisite
successful treatment. Here, we investigated whether concentration of human thymidine …

Thymidine kinase 1–a prognostic and diagnostic indicator in ALL and AML patients

KL O'Neill, F Zhang, H Li, DG Fuja, BK Murray - Leukemia, 2007 - nature.com
1 Locatelli F, Nollke P, Zecca M, Korthof E, Lanino E, Peters C et al. Hematopoietic stem cell
transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of …

Membrane expression of thymidine kinase 1 and potential clinical relevance in lung, breast, and colorectal malignancies

EG Weagel, W Burrup, R Kovtun, EJ Velazquez… - Cancer Cell …, 2018 - Springer
Background Lung, breast, and colorectal malignancies are the leading cause of cancer-
related deaths in the world causing over 2.8 million cancer-related deaths yearly. Despite …