Biosensors integrated 3D organoid/organ-on-a-chip system: A real-time biomechanical, biophysical, and biochemical monitoring and characterization

S Liu, S Kumari, H He, P Mishra, BN Singh… - Biosensors and …, 2023 - Elsevier
As a full-fidelity simulation of human cells, tissues, organs, and even systems at the
microscopic scale, Organ-on-a-Chip (OOC) has significant ethical advantages and …

Cell-based biosensors and their application in biomedicine

Q Liu, C Wu, H Cai, N Hu, J Zhou, P Wang - Chemical reviews, 2014 - ACS Publications
A biosensor is an analytical device that can be used for detecting analytes and combines a
biological component with a physicochemical detecting transducer. In recent years …

Advancement of sensor integrated organ-on-chip devices

GA Clarke, BX Hartse, AE Niaraki Asli, M Taghavimehr… - Sensors, 2021 - mdpi.com
Organ-on-chip devices have provided the pharmaceutical and tissue engineering worlds
much hope since they arrived and began to grow in sophistication. However, limitations for …

Organ-on-a-chip engineering: Toward bridging the gap between lab and industry

Q Ramadan, M Zourob - Biomicrofluidics, 2020 - pubs.aip.org
Organ-on-a-chip (OOC) is a very ambitious emerging technology with a high potential to
revolutionize many medical and industrial sectors, particularly in preclinical-to-clinical …

A multi-chamber microfluidic intestinal barrier model using Caco-2 cells for drug transport studies

HY Tan, S Trier, UL Rahbek, M Dufva, JP Kutter… - PloS one, 2018 - journals.plos.org
This paper presents the design and fabrication of a multi-layer and multi-chamber microchip
system using thiol-ene 'click chemistry'aimed for drug transport studies across tissue barrier …

Microfluidic impedance flow cytometry enabling high-throughput single-cell electrical property characterization

J Chen, C Xue, Y Zhao, D Chen, MH Wu… - International journal of …, 2015 - mdpi.com
This article reviews recent developments in microfluidic impedance flow cytometry for high-
throughput electrical property characterization of single cells. Four major perspectives of …

Measurement of barrier tissue integrity with an organic electrochemical transistor.

LH Jimison, SA Tria, D Khodagholy… - … (Deerfield Beach, Fla …, 2012 - europepmc.org
The integration of an organic electrochemical transistor with human barrier tissue cells
provides a novel method for assessing toxicology of compounds in vitro. Minute variations in …

Organ-on-a-chip platforms integrated with biosensors for precise monitoring of the cells and cellular microenvironment

W Yang, T Li, S Liao, J Zhou, L Huang - TrAC Trends in Analytical …, 2024 - Elsevier
Abstract Organs-on-chips (OoCs) are in vitro models that simulate the anatomical and
physiological structure of human organs at the micro-scale level. With the advantages of …

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.

S Gordon, M Daneshian, J Bouwstra, F Caloni… - …, 2015 - researchonline.ljmu.ac.uk
Models of the outer epithelia of the human body-namely the skin, the intestine and the lung-
have found valid applications in both research and industrial settings as attractive …

Pioneering better science through the 3Rs: an introduction to the national centre for the replacement, refinement, and reduction of animals in research (NC3Rs)

N Burden, K Chapman, F Sewell… - Journal of the American …, 2015 - ingentaconnect.com
The National Centre for the Replacement, Refinement, and Reduction of Animals in
Research (NC3Rs) is an independent scientific organization that is based in the United …