Ischemic heart disease is the leading cause of death worldwide. Myocardial infarction
results in an irreversible loss of cardiomyocytes with subsequent adverse remodeling and …

Abstract The Third Universal Definition of Myocardial Infarction (MI) requires cardiac
myocyte necrosis with an increase and/or a decrease in a patient's plasma of cardiac …

Aims Naturally secreted nanovesicles known as exosomes are required for the regenerative
effects of cardiosphere-derived cells (CDCs), and exosomes mimic the benefits of CDCs in …

Abstract Aims Cardiosphere-derived cells (CDCs) are cardiac progenitor cells that exhibit
disease-modifying bioactivity in various models of cardiomyopathy and in previous clinical …

Ischemic injury in the heart induces an inflammatory cascade that both repairs damage and
exacerbates scar tissue formation. Cardiosphere-derived cells (CDCs) are a stem-like …

Cardiosphere‐derived cells (CDC s) reduce myocardial infarct size via secreted
extracellular vesicles (CDC‐EVs), including exosomes, which alter macrophage …

Given the rising prevalence of cardiovascular disease worldwide and the limited therapeutic
options for severe heart failure, novel technologies that harness the regenerative capacity of …

In the adult, tissue repair after injury is generally compromised by fibrosis, which maintains
tissue integrity with scar formation but does not restore normal architecture and function. The …

Due to the biological complexity of the cardiovascular system, the animal model is an urgent
pre-clinical need to advance our knowledge of cardiovascular disease and to explore new …

Rationale: Patients with single ventricle physiology are at high risk of mortality resulting from
ventricular dysfunction. The preliminary results of the phase 1 trial showed that cardiosphere …