Membrane electroporation and electropermeabilization: mechanisms and models

T Kotnik, L Rems, M Tarek… - Annual review of …, 2019‏ - annualreviews.org
Exposure of biological cells to high-voltage, short-duration electric pulses causes a transient
increase in their plasma membrane permeability, allowing transmembrane transport of …

The 2012 plasma roadmap

S Samukawa, M Hori, S Rauf… - Journal of Physics D …, 2012‏ - iopscience.iop.org
Low-temperature plasma physics and technology are diverse and interdisciplinary fields.
The plasma parameters can span many orders of magnitude and applications are found in …

Plasma medicine: an introductory review

MG Kong, G Kroesen, G Morfill, T Nosenko… - new Journal of …, 2009‏ - iopscience.iop.org
This introductory review on plasma health care is intended to provide the interested reader
with a summary of the current status of this emerging field, its scope, and its broad …

Applied plasma medicine

G Fridman, G Friedman, A Gutsol… - Plasma processes …, 2008‏ - Wiley Online Library
An emerging field of plasma medicine is discussed, where non‐equilibrium plasmas are
shown to be able to initiate, promote, control, and catalyze various complex behaviors and …

Cell membrane electroporation-Part 1: The phenomenon

T Kotnik, P Kramar, G Pucihar… - IEEE Electrical …, 2012‏ - ieeexplore.ieee.org
Each biological cell, trillions of which build our bodies, is enveloped by its plasma
membrane. Composed largely of a bilayer (double layer) of lipids just two molecules thick …

Advanced physical techniques for gene delivery based on membrane perforation

X Du, J Wang, Q Zhou, L Zhang, S Wang, Z Zhang… - Drug …, 2018‏ - Taylor & Francis
Gene delivery as a promising and valid tool has been used for treating many serious
diseases that conventional drug therapies cannot cure. Due to the advancement of physical …

Bioelectric effects of intense nanosecond pulses

KH Schoenbach, SJ Hargrave, RP Joshi… - … on Dielectrics and …, 2007‏ - ieeexplore.ieee.org
Electrical models for biological cells predict that reducing the duration of applied electrical
pulses to values below the charging time of the outer cell membrane (which is on the order …

Nanoelectropulse-driven membrane perturbation and small molecule permeabilization

PT Vernier, Y Sun, MA Gundersen - BMC cell biology, 2006‏ - Springer
Background Nanosecond, megavolt-per-meter pulsed electric fields scramble membrane
phospholipids, release intracellular calcium, and induce apoptosis. Flow cytometric and …

Long‐lasting plasma membrane permeabilization in mammalian cells by nanosecond pulsed electric field (nsPEF)

AG Pakhomov, JF Kolb, JA White… - … : Journal of the …, 2007‏ - Wiley Online Library
The barrier function of plasma membrane in nsPEF‐exposed mammalian cells was
examined using whole‐cell patch‐clamp techniques. A specialized setup for nsPEF …

A new pulsed electric field therapy for melanoma disrupts the tumor's blood supply and causes complete remission without recurrence

R Nuccitelli, X Chen, AG Pakhomov… - … journal of cancer, 2009‏ - Wiley Online Library
We have discovered a new, ultrafast therapy for treating skin cancer that is extremely
effective with a total electric field exposure time of only 180 μsec. The application of 300 high …