Abstract G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that
form within guanine-rich strands of regulatory genomic regions. G4s have been extensively …

Since its first observation in 1907, ortho-quinone methide (o-QM) has occupied a strategic
place within the framework of reactive intermediates in organic synthesis. In recent years, o …

Abstract ortho‐Quinone methides (o‐QMs) are emerging as highly useful intermediates, the
inherent reactivity of which can be used in linchpin reactions for the construction of complex …

Ortho-quinone methides are important synthetic intermediates and widely implicated in
biological processes. In this Synopsis, recent advances concerning the synthesis and utility …

The highly enantioselective conjugate addition of enamides and enecarbamates to in situ‐
generated ortho‐quinone methides, upon subsequent N, O‐acetalization, gives rise to …

A novel and efficient method for the generation of o-quinone methide intermediates was
developed from the readily available 2-tosylalkylphenols under the mild basic conditions …

We have developed novel G-quadruplex (G-4) ligand/alkylating hybrid structures, tethering
the naphthalene diimide moiety to quaternary ammonium salts of Mannich bases, as …

Quinone methides (QMs) are considered to be highly reactive intermediates because of their
aromatization both in chemical and biological systems. Being highly accessible, quinone …

A one-step protecting-group-free synthesis of both 6-hydroxy-naphthalene-2-carbaldehyde
and the bifunctional binaphthalenyl derivative afforded 6-hydroxymethylnaphthalen-2-ol, 6 …

We describe several new aromatic nitrogen mustards with various aromatic substituents and
boronic esters that can be activated with H2O2 to efficiently cross-link DNA. In vitro studies …