Analyzing proteins from single cells by tandem mass spectrometry (MS) has recently
become technically feasible. While such analysis has the potential to accurately quantify …

The Electrospray Ionization (ESI) is a soft ionization technique extensively used for
production of gas phase ions (without fragmentation) of thermally labile large …

Matrix‐dependent signal suppression or enhancement represents a major drawback in
quantitative analysis with liquid chromatography coupled to atmospheric pressure ionization …

When non-mass spectrometrists are talking about mass spectrometry it rather often sounds
as if they were telling a story out of Poe's Tales of Mystery and Imagi-tion. Indeed, mass …

A brief account of the mechanisms by which ions in solution are converted to ions in the gas
phase is given on the basis of information available in the literature and the four companion …

The most widely used ionization techniques in liquid chromatography–mass spectrometry
(LC–MS) are electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI) …

Matrix Assisted Laser Desorption/Ionization (MALDI) is a very widely used analytical
method, but has been developed in a highly empirical manner. Deeper understanding of …

The origin of the extent of charging and the mechanism by which multiply charged ions are
formed in electrospray ionization have been hotly debated for over a decade. Many factors …

This review addresses the determination of the internal energy of ions produced by
electrospray ionization (ESI) sources, and the influence of the internal energy on analyte …

A droplet pickup and other mechanisms have been suggested for the ionization of
biomolecules like peptides and proteins by desorption electrospray ionization. To verify this …