How preclinical models evolved to resemble the diagnostic criteria of drug addiction

A Belin-Rauscent, M Fouyssac, A Bonci, D Belin - Biological psychiatry, 2016‏ - Elsevier
Drug addiction is a complex neuropsychiatric disorder that affects a subset of the individuals
who take drugs. It is characterized by maladaptive drug-seeking habits that are maintained …

The Homer1 family of proteins at the crossroad of dopamine-glutamate signaling: An emerging molecular “Lego” in the pathophysiology of psychiatric disorders. A …

A de Bartolomeis, A Barone, EF Buonaguro… - Neuroscience & …, 2022‏ - Elsevier
Once considered only scaffolding proteins at glutamatergic postsynaptic density (PSD),
Homer1 proteins are increasingly emerging as multimodal adaptors that integrate different …

Context-induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons

FJ Rubio, QR Liu, X Li, FC Cruz, RM Leao… - Journal of …, 2015‏ - jneurosci.org
Context-induced reinstatement of drug seeking is a well established animal model for
assessing the neural mechanisms underlying context-induced drug relapse, a major factor …

Homer1/mGluR5 activity moderates vulnerability to chronic social stress

KV Wagner, J Hartmann, C Labermaier… - …, 2015‏ - nature.com
Stress-induced psychiatric disorders, such as depression, have recently been linked to
changes in glutamate transmission in the central nervous system. Glutamate signaling is …

Alcohol-drinking under limited-access procedures during mature adulthood accelerates the onset of cognitive impairment in mice

CL Jimenez Chavez, E Van Doren… - Frontiers in Behavioral …, 2022‏ - frontiersin.org
A history of heavy drinking increases vulnerability to, and the severity of, Alzheimer's
disease (AD) and related dementias, with alcohol use disorder identified as the strongest …

Binge alcohol drinking by mice requires intact group1 metabotropic glutamate receptor signaling within the central nucleus of the amygdale

DK Cozzoli, J Courson, MG Wroten… - …, 2014‏ - nature.com
Despite the fact that binge alcohol drinking (intake resulting in blood alcohol concentrations
(BACs)⩾ 80 mg% within a 2-h period) is the most prevalent form of alcohol-use disorders …

Adolescent mice are resilient to alcohol withdrawal-induced anxiety and changes in indices of glutamate function within the nucleus accumbens

KM Lee, MA Coelho, HA McGregor… - Frontiers in cellular …, 2016‏ - frontiersin.org
Binge-drinking is the most prevalent form of alcohol abuse and while an early life history of
binge-drinking is a significant risk factor for subsequent alcoholism and co-morbid affective …

mGluR1 within the nucleus accumbens regulates alcohol intake in mice under limited-access conditions

EN Lum, RR Campbell, C Rostock, KK Szumlinski - Neuropharmacology, 2014‏ - Elsevier
Idiopathic or alcohol-induced increases in the expression and function of the Group1
metabotropic glutamate receptor subtype 1 (mGluR1) within the extended amygdala are …

Prefrontal glutamate correlates of methamphetamine sensitization and preference

KD Lominac, SG Quadir, HM Barrett… - European Journal of …, 2016‏ - Wiley Online Library
Methamphetamine (MA) is a widely misused, highly addictive psychostimulant that elicits
pronounced deficits in neurocognitive function related to hypo‐functioning of the prefrontal …

Chemogenetic inhibition of corticostriatal circuits reduces cued reinstatement of methamphetamine seeking

AM Kearns, BM Siemsen, JL Hopkins… - Addiction …, 2022‏ - Wiley Online Library
Methamphetamine (meth) causes enduring changes within the medial prefrontal cortex
(mPFC) and the nucleus accumbens (NA). Projections from the mPFC to the NA have a …