The p53 family of tumor suppressors, which includes p53, p63, and p73, has a critical role in
many biological processes, such as cell cycle arrest, apoptosis, and differentiation. In …

MicroRNAs (miRNAs) and RNA-binding proteins (RBPs) are important regulators of mRNA
translation and stability in eukaryotes. While miRNAs can only bind their target mRNAs in …

An increasing number of men are fathering children at an older age than in the past. While
advanced maternal age has long been recognized as a risk factor for adverse reproductive …

With the onset of resistance, ovarian cancer cells display almost unpredictable adaptive
potential. This may derive from the tumor genetic ancestry and can be additionally tailored …

Cisplatin (CDDP)-based chemotherapy is commonly used to treat advanced non-small cell
lung cancer (NSCLC). However, the efficacy is limited by the development of drug …

Introduction Only a proportion of triple-negative breast cancer (TNBC) is immunotherapy-
responsive. We hypothesized that the tumor microenvironment (TME) influences the …

p53 is the most frequently mutated gene in human cancers and mutant p53 has a gain of
function (GOF) that promotes tumor progression and therapeutic resistance. One of the …

Cancer is the second leading cause of death globally. Abnormity in gene expression
regulation characterizes the trajectory of tumor development and progression. RNA-binding …

TP63 is expressed as TAp63 and ΔNp63 from the P1 and P2 promoters, respectively. While
TAp63 and ΔNp63 are expressed as three TAp63α/β/γ and ΔNp63α/β/γ due to alternative …

Simple Summary Hepatocellular carcinoma (HCC) represents the fourth leading cause of
cancer-related death in the world. Sorafenib, a first-line chemotherapeutic drug that inhibits …