What makes Aspergillus fumigatus a successful pathogen? Genes and molecules involved in invasive aspergillosis

A Abad, JV Fernández-Molina, J Bikandi… - Revista iberoamericana …, 2010 - Elsevier
Aspergillus fumigatus is an opportunistic pathogen that causes 90% of invasive aspergillosis
(IA) due to Aspergillus genus, with a 50–95% mortality rate. It has been postulated that …

Aspergillus fumigatus and related species

JA Sugui, KJ Kwon-Chung… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
The genus Aspergillus contains etiologic agents of aspergillosis. The clinical manifestations
of the disease range from allergic reaction to invasive pulmonary infection. Among the …

Pathogenicity and virulence of Aspergillus fumigatus

K Earle, C Valero, DP Conn, G Vere, PC Cook… - Virulence, 2023 - Taylor & Francis
Pulmonary infections caused by the mould pathogen Aspergillus fumigatus are a major
cause of morbidity and mortality globally. Compromised lung defences arising from …

The Aspergillus fumigatus cell wall integrity signaling pathway: drug target, compensatory pathways, and virulence

V Valiante, J Macheleidt, M Föge… - Frontiers in …, 2015 - frontiersin.org
Aspergillus fumigatus is the most important airborne fungal pathogen, causing severe
infections with invasive growth in immunocompromised patients. The fungal cell wall (CW) …

Chemistry and biology of galactofuranose‐containing polysaccharides

MR Richards, TL Lowary - ChemBioChem, 2009 - Wiley Online Library
The thermodynamically less stable form of galactose—galactofuranose (Galf)—is essential
for the viability of several pathogenic species of bacteria and protozoa but absent in this form …

Aspergillus Fumigatus: Cell Wall Polysaccharides, their Biosynthesis and Organization

A Gastebois, C Clavaud, V Aimanianda… - Future …, 2009 - Taylor & Francis
Aspergillus fumigatus is the most prevalent thermophilic inhabitants of decaying vegetation
and one of the most important human opportunistic fungal pathogens. Like other fungi, A …

Galactomannan Produced by Aspergillus fumigatus: An Update on the Structure, Biosynthesis and Biological Functions of an Emblematic Fungal Biomarker

T Fontaine, JP Latgé - Journal of Fungi, 2020 - mdpi.com
The galactomannan (GM) that is produced by the human fungal pathogen Aspergillus
fumigatus is an emblematic biomarker in medical mycology. The GM is composed of two …

Comparative bioinformatics analysis of the mammalian and bacterial glycomes

A Adibekian, P Stallforth, ML Hecht, DB Werz… - Chemical …, 2011 - pubs.rsc.org
A comparative analysis of bacterial and mammalian glycomes based on the statistical
analysis of two major carbohydrate databases, Bacterial CarbohydrateStructure Data Base …

Galactofuranose in eukaryotes: aspects of biosynthesis and functional impact

B Tefsen, AFJ Ram, I Van Die, FH Routier - Glycobiology, 2012 - academic.oup.com
Galactofuranose (Gal f) is the five-membered ring form of galactose. It is widely distributed
among several branches of the eukaryotic kingdom. This review highlights recent advances …

A Role for the Unfolded Protein Response (UPR) in Virulence and Antifungal Susceptibility in Aspergillus fumigatus

DL Richie, L Hartl, V Aimanianda, MS Winters… - PLoS …, 2009 - journals.plos.org
Filamentous fungi rely heavily on the secretory pathway, both for the delivery of cell wall
components to the hyphal tip and the production and secretion of extracellular hydrolytic …