Advanced techniques for detecting protein misfolding and aggregation in cellular environments

Y Bai, S Zhang, H Dong, Y Liu, C Liu… - Chemical Reviews, 2023 - ACS Publications
Protein misfolding and aggregation, a key contributor to the progression of numerous
neurodegenerative diseases, results in functional deficiencies and the creation of harmful …

Opportunities and Challenges in Applying Solid‐State NMR Spectroscopy in Organic Mechanochemistry

IAA Silva, E Bartalucci, C Bolm… - Advanced Materials, 2023 - Wiley Online Library
In recent years it is shown that mechanochemical strategies can be beneficial in directed
conversions of organic compounds. Finding new reactions proved difficult, and due to the …

Dipolar Recoupling in Rotating Solids

V Ladizhansky, RS Palani, M Mardini… - Chemical …, 2024 - ACS Publications
Magic angle spinning (MAS) nuclear magnetic resonance (NMR) has evolved significantly
over the past three decades and established itself as a vital tool for the structural analysis of …

Sensitivity-enhanced multidimensional solid-state NMR spectroscopy by optimal-control-based transverse mixing sequences

J Blahut, MJ Brandl, T Pradhan, B Reif… - Journal of the …, 2022 - ACS Publications
Recently, proton-detected magic-angle spinning (MAS) solid-state nuclear magnetic
resonance (NMR) spectroscopy has become an attractive tool to study the structure and …

Molecular architecture of chitin and chitosan-dominated cell walls in zygomycetous fungal pathogens by solid-state NMR

Q Cheng, MC Dickwella Widanage, JR Yarava… - Nature …, 2024 - nature.com
Zygomycetous fungal infections pose an emerging medical threat among individuals with
compromised immunity and metabolic abnormalities. Our pathophysiological understanding …

High and fast: NMR protein–proton side-chain assignments at 160 kHz and 1.2 GHz

M Callon, D Luder, AA Malär, T Wiegand, V Římal… - Chemical …, 2023 - pubs.rsc.org
The NMR spectra of side-chain protons in proteins provide important information, not only
about their structure and dynamics, but also about the mechanisms that regulate interactions …

Selective detection of intermediate-amplitude motion by solid-state NMR

P Duan, M Hong - The Journal of Physical Chemistry B, 2024 - ACS Publications
The coexistence of rigid and mobile molecules or molecular segments abounds in
biomolecular assemblies. Examples include the carbohydrate-rich cell walls of plants and …

Selective methods promote protein solid-state NMR

B Han, J Yang, Z Zhang - The Journal of Physical Chemistry …, 2024 - ACS Publications
Solid-state nuclear magnetic resonance (ssNMR) is indispensable for studying the
structures, dynamics, and interactions of insoluble proteins in native or native-like …

Cellular applications of DNP solid‐state NMR–state of the art and a look to the future

D Beriashvili, J Zhou, Y Liu, GE Folkers… - … –A European Journal, 2024 - Wiley Online Library
Sensitivity enhanced dynamic nuclear polarization solid‐state NMR is emerging as a
powerful technique for probing the structural properties of conformationally homogenous …

The evolution of paramagnetic NMR as a tool in structural biology

E Ravera, L Gigli, L Fiorucci, C Luchinat… - Physical Chemistry …, 2022 - pubs.rsc.org
Paramagnetic NMR data contain extremely accurate long-range information on
metalloprotein structures and, when used in the frame of integrative structural biology …