Dietary sources, health benefits, and risks of caffeine
A Saimaiti, DD Zhou, J Li, RG **ong… - Critical Reviews in …, 2023 - Taylor & Francis
Dietary intake of caffeine has significantly increased in recent years, and beneficial and
harmful effects of caffeine have been extensively studied. This paper reviews antioxidant …
harmful effects of caffeine have been extensively studied. This paper reviews antioxidant …
Caffeine for Prevention of Alzheimer's Disease: Is the A2A Adenosine Receptor Its Target?
Alzheimer's disease (AD) is the most prevalent kind of dementia with roughly 135 million
cases expected in the world by 2050. Unfortunately, current medications for the treatment of …
cases expected in the world by 2050. Unfortunately, current medications for the treatment of …
Balancing G protein selectivity and efficacy in the adenosine A2A receptor
The adenosine A2A receptor (A2AR) engages several G proteins, notably Go and its
cognate Gs protein. This coupling promiscuity is facilitated by a dynamic ensemble, revealed …
cognate Gs protein. This coupling promiscuity is facilitated by a dynamic ensemble, revealed …
A2A Adenosine Receptor Antagonists in Neurodegenerative Diseases
Background: Alzheimer's disease (AD) is the most common form of dementia worldwide,
with approximately 6 million cases reported in America in 2020. The clinical signs of AD …
with approximately 6 million cases reported in America in 2020. The clinical signs of AD …
An Expanded Narrative Review of Neurotransmitters on Alzheimer's Disease: The Role of Therapeutic Interventions on Neurotransmission
Alzheimer's disease (AD) is a progressive neurodegenerative disease. The accumulation of
amyloid-β (Aβ) plaques and tau neurofibrillary tangles are the key players responsible for …
amyloid-β (Aβ) plaques and tau neurofibrillary tangles are the key players responsible for …
Pathophysiological Role and Medicinal Chemistry of A2A Adenosine Receptor Antagonists in Alzheimer's Disease
The A2A adenosine receptor is a protein belonging to a family of four GPCR adenosine
receptors. It is involved in the regulation of several pathophysiological conditions in both the …
receptors. It is involved in the regulation of several pathophysiological conditions in both the …
Therapeutic strategies aimed at improving neuroplasticity in Alzheimer disease
MF Colavitta, FJ Barrantes - Pharmaceutics, 2023 - mdpi.com
Alzheimer disease (AD) is the most prevalent form of dementia among elderly people.
Owing to its varied and multicausal etiopathology, intervention strategies have been highly …
Owing to its varied and multicausal etiopathology, intervention strategies have been highly …
Blockade of adenosine A2A receptors reverses early spatial memory defects in the APP/PS1 mouse model of Alzheimer's disease by promoting synaptic plasticity of …
Q Ji, Y Yang, Y **ong, YJ Zhang, J Jiang… - Alzheimer's Research & …, 2023 - Springer
Background The over-activation of adenosine A2A receptors (A2AR) is closely implicated in
cognitive impairments of Alzheimer's disease (AD). Growing evidence shows that A2AR …
cognitive impairments of Alzheimer's disease (AD). Growing evidence shows that A2AR …
A2A Adenosine Receptor: A Possible Therapeutic Target for Alzheimer's Disease by Regulating NLRP3 Inflammasome Activity?
The A2A adenosine receptor, a member of the P1 purinergic receptor family, plays a crucial
role in the pathophysiology of different neurodegenerative illnesses, including Alzheimer's …
role in the pathophysiology of different neurodegenerative illnesses, including Alzheimer's …
[HTML][HTML] Caffeine: A Multifunctional Efficacious Molecule with Diverse Health Implications and Emerging Delivery Systems
X Song, M Singh, KE Lee, R Vinayagam… - International Journal of …, 2024 - mdpi.com
Natural caffeine is found in many plants, including coffee beans, cacao beans, and tea
leaves. Around the world, many beverages, including coffee, tea, energy drinks, and some …
leaves. Around the world, many beverages, including coffee, tea, energy drinks, and some …