Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

Protein lysine methylation is a crucial post-translational modification that regulates the
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …

Mitochondrial cristae, infoldings of the mitochondrial inner membrane, undergo aberrant
changes in their architecture with age. However, the underlying molecular mechanisms and …

The ever-growing compendium of genetic variants associated with human pathologies
demands new methods to study genotype–phenotype relationships in complex tissues in a …

Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterized
by difficulties in social interaction, language development delays, repeated body …

Progressive neuronal dysfunction and death are key features of neurodegenerative
diseases; therefore, promoting neurogenesis in neurodegenerative diseases is crucial. With …

Clustered regularly interspaced short palindromic repeats (CRISPR) screening coupled with
single-cell RNA sequencing has emerged as a powerful tool to characterize the effects of …

Histone modifying enzymes play critical roles in many key cellular processes and are
appealing proteins for targeting by small molecules in disease. However, while the functions …

Molecular mechanisms underlying adaptive targeted therapy resistance in pancreatic ductal
adenocarcinoma (PDAC) are poorly understood. Here, we identify SETD5 as a major driver …

Histone modification is an important form of epigenetic regulation. Thereinto, histone
methylation is a critical determination of chromatin states, participating in multiple cellular …