Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics

S Qin, W **ao, C Zhou, Q Pu, X Deng, L Lan… - Signal transduction and …, 2022 - nature.com
Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen that
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …

Leveraging artificial intelligence in the fight against infectious diseases

F Wong, C de la Fuente-Nunez, JJ Collins - Science, 2023 - science.org
Despite advances in molecular biology, genetics, computation, and medicinal chemistry,
infectious disease remains an ominous threat to public health. Addressing the challenges …

Pathogenesis of the Pseudomonas aeruginosa Biofilm: A Review

FF Tuon, LR Dantas, PH Suss, VS Tasca Ribeiro - Pathogens, 2022 - mdpi.com
Pseudomonas aeruginosa is associated with several human infections, mainly related to
healthcare services. In the hospital, it is associated with resistance to several antibiotics …

Pseudomonas aeruginosa Biofilms

MTT Thi, D Wibowo, BHA Rehm - International journal of molecular …, 2020 - mdpi.com
Pseudomonas aeruginosa is an opportunistic human pathogen causing devastating acute
and chronic infections in individuals with compromised immune systems. Its highly notorious …

Therapeutic Strategies for Emerging Multidrug-Resistant Pseudomonas aeruginosa

AJ Kunz Coyne, A El Ghali, D Holger, N Rebold… - Infectious diseases and …, 2022 - Springer
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) Pseudomonas aeruginosa
isolates are frequent causes of serious nosocomial infections that may compromise the …

Epidemiology and treatment of multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa infections

JP Horcajada, M Montero, A Oliver, L Sorlí… - Clinical microbiology …, 2019 - Am Soc Microbiol
In recent years, the worldwide spread of the so-called high-risk clones of multidrug-resistant
or extensively drug-resistant (MDR/XDR) Pseudomonas aeruginosa has become a public …

[HTML][HTML] Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and alternative therapeutic strategies

Z Pang, R Raudonis, BR Glick, TJ Lin, Z Cheng - Biotechnology advances, 2019 - Elsevier
Pseudomonas aeruginosa is an opportunistic pathogen that is a leading cause of morbidity
and mortality in cystic fibrosis patients and immunocompromised individuals. Eradication of …

Antimicrobial peptides, conventional antibiotics, and their synergistic utility for the treatment of drug‐resistant infections

Y Zhu, W Hao, X Wang, J Ouyang… - Medicinal Research …, 2022 - Wiley Online Library
Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), are important
effector immune defense molecules in multicellular organisms. AMPs exert their …

Comprehensive review of antimicrobial activities of plant flavonoids

I Górniak, R Bartoszewski, J Króliczewski - Phytochemistry reviews, 2019 - Springer
Flavonoids are one of the largest classes of small molecular secondary metabolites
produced in different parts of the plant. They display a wide range of pharmacological and …

How to enter a bacterium: bacterial porins and the permeation of antibiotics

JD Prajapati, U Kleinekathöfer… - Chemical …, 2021 - ACS Publications
Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …