In postnatal organisms, insulin is well known as an essential anabolic hormone responsible
for maintaining glucose homeostasis. Its biosynthesis by the pancreatic beta cell has been …

Human pluripotent stem cells (PSCs) are used as a platform for therapeutic purposes such
as cell transplantation therapy and drug discovery. Another motivation for studying PSCs is …

Somites (SMs) comprise a transient stem cell population that gives rise to multiple cell types,
including dermatome (D), myotome (MYO), sclerotome (SCL) and syndetome (SYN) cells …

Peptide hormones, usually considered to be endocrine factors responsible for
communication between tissues remotely located from each other, are increasingly being …

During vertebrate development, progenitor cells give rise to tissues and organs through a
complex choreography that commences at gastrulation. A hallmark event of gastrulation is …

Insulin and insulin-like-growth-factor 1 (IGF1) are components of the uterine secretions. As
potent growth factors they influence early embryo development. The underlying molecular …

Ghrelin is a regulatory peptide in glucose homeostasis in animal species. Its effect in the
avian embryo is unclear. The aim of this study was to investigate the effects of in ovo ghrelin …

In this study, we generated self-assembly cardiac organoids (COs) from human pluripotent
stem cells by dual-phase modulation of Wnt/β-catenin pathway, utilizing CHIR99021 and …

Several human diseases are associated with the NUAK1 and NUAK2 genes. These genes
encode kinases, members of the AMPK-related kinases (ARK) gene family. Both NUAK1 …

In mammals, insulin primarily lowers plasma glucose (P Glu) by increasing its uptake into
tissues. Studies have also shown that insulin lowers P Glu in mammals by modulating …