Mechanisms, regulation and functions of the unfolded protein response
Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …
Endoplasmic reticulum stress signals in the tumour and its microenvironment
Protein handling, modification and folding in the endoplasmic reticulum (ER) are tightly
regulated processes that determine cell function, fate and survival. In several tumour types …
regulated processes that determine cell function, fate and survival. In several tumour types …
Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)
X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …
Signal integration in the endoplasmic reticulum unfolded protein response
The endoplasmic reticulum (ER) responds to the accumulation of unfolded proteins in its
lumen (ER stress) by activating intracellular signal transduction pathways—cumulatively …
lumen (ER stress) by activating intracellular signal transduction pathways—cumulatively …
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
The ability to respond to perturbations in endoplasmic reticulum (ER) function is a
fundamentally important property of all cells, but ER stress can also lead to apoptosis. In …
fundamentally important property of all cells, but ER stress can also lead to apoptosis. In …
Mechanisms of substrate processing during ER-associated protein degradation
JC Christianson, E Jarosch, T Sommer - Nature Reviews Molecular Cell …, 2023 - nature.com
Maintaining proteome integrity is essential for long-term viability of all organisms and is
overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes …
overseen by intrinsic quality control mechanisms. The secretory pathway of eukaryotes …
Genomic expression programs in the response of yeast cells to environmental changes
We explored genomic expression patterns in the yeast Saccharomyces cerevisiae
responding to diverse environmental transitions. DNA microarrays were used to measure …
responding to diverse environmental transitions. DNA microarrays were used to measure …
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
HP Harding, Y Zhang, D Ron - Nature, 1999 - nature.com
Protein synthesis and the folding of the newly synthesized proteins into the correct three-
dimensional structure are coupled in cellular compartments of the exocytosis pathway by a …
dimensional structure are coupled in cellular compartments of the exocytosis pathway by a …
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
Malfolded proteins in the endoplasmic reticulum (ER) induce cellular stress and activate c-
Jun amino-terminal kinases (JNKs or SAPKs). Mammalian homologs of yeast IRE1, which …
Jun amino-terminal kinases (JNKs or SAPKs). Mammalian homologs of yeast IRE1, which …
Structure and molecular mechanism of ER stress signaling by the unfolded protein response signal activator IRE1
CJ Adams, MC Kopp, N Larburu, PR Nowak… - Frontiers in molecular …, 2019 - frontiersin.org
The endoplasmic reticulum (ER) is an important site for protein folding and maturation in
eukaryotes. The cellular requirement to synthesize proteins within the ER is matched by its …
eukaryotes. The cellular requirement to synthesize proteins within the ER is matched by its …