Malaria: biology and disease

AF Cowman, J Healer, D Marapana, K Marsh - Cell, 2016 - cell.com
Malaria has been a major global health problem of humans through history and is a leading
cause of death and disease across many tropical and subtropical countries. Over the last …

Cell division in apicomplexan parasites

ME Francia, B Striepen - Nature Reviews Microbiology, 2014 - nature.com
Toxoplasma gondii and Plasmodium falciparum are important human pathogens. These
parasites and many of their apicomplexan relatives undergo a complex developmental …

PlasmoDB: a functional genomic database for malaria parasites

C Aurrecoechea, J Brestelli, BP Brunk… - Nucleic acids …, 2009 - academic.oup.com
Abstract PlasmoDB (http://PlasmoDB. org) is a functional genomic database for Plasmodium
spp. that provides a resource for data analysis and visualization in a gene-by-gene or …

Heterochromatin protein 1 secures survival and transmission of malaria parasites

NMB Brancucci, NL Bertschi, L Zhu, I Niederwieser… - Cell host & …, 2014 - cell.com
Clonally variant expression of surface antigens allows the malaria parasite Plasmodium
falciparum to evade immune recognition during blood stage infection and secure malaria …

Antigenic Variation in Plasmodium falciparum

A Scherf, JJ Lopez-Rubio, L Riviere - Annu. Rev. Microbiol., 2008 - annualreviews.org
The persistence of the human malaria parasite Plasmodium falciparum during blood stage
proliferation in its host depends on the successive expression of variant molecules at the …

PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum

L Jiang, J Mu, Q Zhang, T Ni, P Srinivasan, K Rayavara… - Nature, 2013 - nature.com
The variant antigen Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1),
which is expressed on the surface of P. falciparum-infected red blood cells, is a critical …

A Plasmodium falciparum histone deacetylase regulates antigenic variation and gametocyte conversion

BI Coleman, KM Skillman, RHY Jiang, LM Childs… - Cell host & …, 2014 - cell.com
The asexual forms of the malaria parasite Plasmodium falciparum are adapted for chronic
persistence in human red blood cells, continuously evading host immunity using …

Reconstructing immune phylogeny: new perspectives

GW Litman, JP Cannon, LJ Dishaw - Nature Reviews Immunology, 2005 - nature.com
Numerous studies of the mammalian immune system have begun to uncover profound
interrelationships, as well as fundamental differences, between the adaptive and innate …

Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens

KW Deitsch, SA Lukehart, JR Stringer - Nature Reviews Microbiology, 2009 - nature.com
The complex relationships between infectious organisms and their hosts often reflect the
continuing struggle of the pathogen to proliferate and spread to new hosts, and the need of …

Genome-wide analysis of heterochromatin associates clonally variant gene regulation with perinuclear repressive centers in malaria parasites

JJ Lopez-Rubio, L Mancio-Silva, A Scherf - Cell host & microbe, 2009 - cell.com
Clonally variant gene families underlie phenotypic plasticity in Plasmodium falciparum, a
process indispensable for survival of the pathogen in its human host. Differential …