The genome-sequencing projects are providing a detailed 'parts list'of life. A key to
comprehending this list is understanding the function of each gene and each protein at …

Introduction 3. Complex and cooperative–Signal integration and deterministic signaling 3.1.
Interactions as descriptors of protein function 3.2. Cooperative binding of linear motifs 3.3 …

With the recent exponential increase in protein phosphorylation sites identified by mass
spectrometry, a unique opportunity has arisen to understand the motifs surrounding such …

Signature databases are vital tools for identifying distant relationships in novel sequences
and hence for inferring protein function. InterPro is an integrated documentation resource for …

Abstract Mutations in mammalian Lis1 (Pafah1b1) result in neuronal migration defects.
Several lines of evidence suggest that LIS1 participates in pathways regulating microtubule …

It is difficult to identify genes that predispose to prostate cancer due to late age at diagnosis,
presence of phenocopies within high-risk pedigrees and genetic complexity. A genome …