Acylcarnitines: nomenclature, biomarkers, therapeutic potential, drug targets, and clinical trials
M Dambrova, M Makrecka-Kuka, J Kuka… - Pharmacological …, 2022 - Elsevier
Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …
metabolism pathways. They have historically been used as important diagnostic markers for …
Glucagon-like peptide-1 receptor agonists for treatment of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: an updated meta-analysis of randomized …
To assess the efficacy of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for
treatment of nonalcoholic fatty liver disease (NAFLD) or steatohepatitis (NASH), we …
treatment of nonalcoholic fatty liver disease (NAFLD) or steatohepatitis (NASH), we …
Short chain fatty acids in the colon and peripheral tissues: a focus on butyrate, colon cancer, obesity and insulin resistance
Increased dietary fiber consumption has been associated with many beneficial effects,
including amelioration of obesity and insulin resistance. These effects may be due to the …
including amelioration of obesity and insulin resistance. These effects may be due to the …
Menstrual cycle rhythmicity: metabolic patterns in healthy women
The menstrual cycle is an essential life rhythm governed by interacting levels of
progesterone, estradiol, follicular stimulating, and luteinizing hormones. To study metabolic …
progesterone, estradiol, follicular stimulating, and luteinizing hormones. To study metabolic …
Acylcarnitines—old actors auditioning for new roles in metabolic physiology
Perturbations in metabolic pathways can cause substantial increases in plasma and tissue
concentrations of long-chain acylcarnitines (LCACs). For example, the levels of LCACs and …
concentrations of long-chain acylcarnitines (LCACs). For example, the levels of LCACs and …
Novel biomarkers for prediabetes, diabetes, and associated complications
B Dorcely, K Katz, R Jagannathan… - … syndrome and obesity …, 2017 - Taylor & Francis
The number of individuals with prediabetes is expected to grow substantially and estimated
to globally affect 482 million people by 2040. Therefore, effective methods for diagnosing …
to globally affect 482 million people by 2040. Therefore, effective methods for diagnosing …
Metabolomic profiling identifies novel circulating biomarkers of mitochondrial dysfunction differentially elevated in heart failure with preserved versus reduced ejection …
Background Metabolic impairment is an important contributor to heart failure (HF)
pathogenesis and progression. Dysregulated metabolic pathways remain poorly …
pathogenesis and progression. Dysregulated metabolic pathways remain poorly …
Global analysis of plasma lipids identifies liver-derived acylcarnitines as a fuel source for brown fat thermogenesis
J Simcox, G Geoghegan, JA Maschek, CL Bensard… - Cell metabolism, 2017 - cell.com
Cold-induced thermogenesis is an energy-demanding process that protects endotherms
against a reduction in ambient temperature. Using non-targeted liquid chromatography …
against a reduction in ambient temperature. Using non-targeted liquid chromatography …
Machine learning and semi-targeted lipidomics identify distinct serum lipid signatures in hospitalized COVID-19-positive and COVID-19-negative patients
H Castañé, S Iftimie, G Baiges-Gaya… - Metabolism, 2022 - Elsevier
Background Lipids are involved in the interaction between viral infection and the host
metabolic and immunological responses. Several studies comparing the lipidome of COVID …
metabolic and immunological responses. Several studies comparing the lipidome of COVID …
Metabolomic analysis of obesity, metabolic syndrome, and type 2 diabetes: amino acid and acylcarnitine levels change along a spectrum of metabolic wellness
DM Libert, AS Nowacki, MR Natowicz - PeerJ, 2018 - peerj.com
Background Metabolic syndrome (MS) is a construct used to separate “healthy” from
“unhealthy” obese patients, and is a major risk factor for type 2 diabetes (T2D) and …
“unhealthy” obese patients, and is a major risk factor for type 2 diabetes (T2D) and …