Fruits, vegetables, and other food items contain phytochemicals or secondary metabolites
which may be considered non-essential nutrients but have medicinal importance. These …

The vascular endothelium, a monolayer of endothelial cells (EC), constitutes the inner
cellular lining of arteries, veins and capillaries and therefore is in direct contact with the …

Numerous studies have demonstrated that endothelial cells are capable of undergoing
endothelial to mesenchymal transition (EndMT), a newly recognized type of cellular …

In addition to the roles of endothelial cells (ECs) in physiological processes, ECs actively
participate in both innate and adaptive immune responses. We previously reported that, in …

Background: Endothelial cells (ECs) display considerable functional heterogeneity
depending on the vessel and tissue in which they are located. Whereas these functional …

Since the emergence of regenerative medicine and tissue engineering more than half a
century ago, one obstacle has persisted: the in vitro creation of large-scale vascular tissue (> …

Background: The cells that form the arterial wall contribute to multiple vascular diseases.
The extent of cellular heterogeneity within these populations has not been fully …

Hemostasis encompasses a set of tightly regulated processes that govern blood clotting,
platelet activation, and vascular repair. Upon vascular injury, the hemostatic system initiates …

Hypertension remains the main cause of cardiovascular complications leading to increased
mortality. The discoveries of recent years underline the important role of endothelial …

Abstract Chitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein that mediates
inflammation, macrophage polarization, apoptosis, and carcinogenesis. The expression of …