Structural biologists have traditionally approached cellular complexity in a reductionist
manner in which the cellular molecular components are fractionated and purified before …

The rapid advances in nanotechnology and the ever decreasing size of features in the
microelectronics industry brings with it the need for advanced characterisation with high …

A new method was developed to acquire images automatically at a series of specimen tilts,
as required for tomographic reconstruction. The method uses changes in specimen position …

Cryoelectron microscopy of biological molecules is among the hottest growth areas in
biophysics and structural biology at present, and Frank is arguably the most distinguished …

Positive-strand RNA viruses, a large group including human pathogens such as SARS-
coronavirus (SARS-CoV), replicate in the cytoplasm of infected host cells. Their replication …

Electron microscopic (EM) tomography is providing important new insights into the internal
organization of mitochondria. The standard baffle model for cristae structure, called into …

Eukaryotic flagella and cilia are built on a 9+ 2 array of microtubules plus> 250 accessory
proteins, forming a biological machine called the axoneme. Here we describe the three …

Electron tomography of vitrified cells is a noninvasive three-dimensional imaging technique
that opens up new vistas for exploring the supramolecular organization of the cytoplasm. We …

The cell walls of mycobacteria form an exceptional permeability barrier, and they are
essential for virulence. They contain extractable lipids and long-chain mycolic acids that are …

With a significant role in material sciences, physics,(soft matter) chemistry, and biology, the
transmission electron microscope is one of the most widely applied structural analysis tool to …