Regulation of microRNA function in animals

LFR Gebert, IJ MacRae - Nature reviews Molecular cell biology, 2019 - nature.com
Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as
key regulators of biological processes in animals. These small RNAs form complex networks …

Trends in the development of miRNA bioinformatics tools

L Chen, L Heikkinen, C Wang, Y Yang… - Briefings in …, 2019 - academic.oup.com
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression via
recognition of cognate sequences and interference of transcriptional, translational or …

circAtlas 3.0: a gateway to 3 million curated vertebrate circular RNAs based on a standardized nomenclature scheme

W Wu, F Zhao, J Zhang - Nucleic Acids Research, 2024 - academic.oup.com
Recent studies have demonstrated the important regulatory role of circRNAs, but an in-depth
understanding of the comprehensive landscape of circRNAs across various species still …

[HTML][HTML] The immune landscape of cancer

V Thorsson, DL Gibbs, SD Brown, D Wolf, DS Bortone… - Immunity, 2018 - cell.com
We performed an extensive immunogenomic analysis of more than 10,000 tumors
comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer …

Prediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data

W Liu, X Wang - Genome biology, 2019 - Springer
We perform a large-scale RNA sequencing study to experimentally identify genes that are
downregulated by 25 miRNAs. This RNA-seq dataset is combined with public miRNA target …

CircAtlas: an integrated resource of one million highly accurate circular RNAs from 1070 vertebrate transcriptomes

W Wu, P Ji, F Zhao - Genome biology, 2020 - Springer
Existing circular RNA (circRNA) databases have become essential for transcriptomics.
However, most are unsuitable for mining in-depth information for candidate circRNA …

Tumor associated macrophages-derived exosomes facilitate hepatocellular carcinoma malignance by transferring lncMMPA to tumor cells and activating glycolysis …

M Xu, C Zhou, J Weng, Z Chen, Q Zhou, J Gao… - Journal of Experimental …, 2022 - Springer
Abstract Background Tumor-associated macrophages (TAMs), which form a large part of the
tumor microenvironment, are normally regulated by metabolic reprogramming. However, the …

LncRNADisease 2.0: an updated database of long non-coding RNA-associated diseases

Z Bao, Z Yang, Z Huang, Y Zhou, Q Cui… - Nucleic acids …, 2019 - academic.oup.com
Mounting evidence suggested that dysfunction of long non-coding RNAs (lncRNAs) is
involved in a wide variety of diseases. A knowledgebase with systematic collection and …

Endogenous microRNA sponges: evidence and controversy

DW Thomson, ME Dinger - Nature Reviews Genetics, 2016 - nature.com
The competitive endogenous RNA (ceRNA) hypothesis proposes that transcripts with
shared microRNA (miRNA) binding sites compete for post-transcriptional control. This …

mirDIP 4.1—integrative database of human microRNA target predictions

T Tokar, C Pastrello, AEM Rossos… - Nucleic acids …, 2018 - academic.oup.com
MicroRNAs are important regulators of gene expression, achieved by binding to the gene to
be regulated. Even with modern high-throughput technologies, it is laborious and expensive …