Glia have emerged as important architects of central nervous system (CNS) development
and maintenance. While traditionally glial contributions to CNS development and …

P2Y12 is a G-protein-coupled receptor that is activated upon ADP binding. Considering its
well-established role in platelet activation, blocking P2Y12 has been used as a therapeutic …

Triggering receptor expressed on myeloid cells 2 (Trem2) is a myeloid cell-specific gene
expressed in brain microglia, with variants that are associated with neurodegenerative …

Summary Microglia (MG), the brain-resident macrophages, play major roles in health and
disease via a diversity of cellular states. While embryonic MG display a large heterogeneity …

Acute brain slices represent a workhorse model for studying the central nervous system
(CNS) from nanoscale events to complex circuits. While slice preparation inherently involves …

Abstract LRRK2-G2019S is one of the most common Parkinson's disease (PD)-associated
mutations and has been shown to alter microglial functionality. However, the impact of …

Microglia are the resident immune cells of the central nervous system (CNS). Microglia
originate from erythromyeloid progenitors in the yolk sac at the early embryonic stage, and …

Microglia are highly dynamic cells that play a critical role in tissue homeostasis through the
surveillance of brain parenchyma and response to cues associated with damage. Aging and …

The intricate network of the brain's neurons and synapses poses unparalleled challenges for
research, distinct from other biological studies. This is particularly true when dissecting how …

Immunosurveillance by microglia is a dynamic process in the central nervous system (CNS)
with versatile functions to maintain tissue homeostasis and provide immune defense. A …