Objectives To address the extreme suicide risk period following a suicidal crisis, we aimed to
assess the current evidence for specific healthcare system-based interventions on suicide …

This paper is the forty-first consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Stimulation of the mu-opioid receptor (MOR) on nociceptors with fentanyl can produce
hyperalgesia (opioid-induced hyperalgesia, OIH) and hyperalgesic priming, a model of …

When the nerve tissue is injured, endogenous agonist of melanocortin type 4 (MC4)
receptor, α-MSH, exerts tonic pronociceptive action in the central nervous system …

Bioactive peptides play important roles in various biological processes. However, the
traditional methods for profiling the peptide-interacting proteins require modifications to the …

Morphine tolerance developed after repeated or continuous morphine treatment is a global
health concern hindering the control of chronic pain. In our previous research, we have …

Buprenorphine is an agonist at the mu opioid receptor (MOR) and antagonist at the kappa
(KOR) and delta (DOR) receptors and a nociceptin receptor (NOR) ligand. Buprenorphine …