The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …

Chromatin remodellers were once thought to be highly redundant and nonspecific in their
actions. However, recent human genetic studies demonstrate remarkable biological …

Large-scale cancer genome sequencing studies have revealed that chromatin regulators
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …

Gastric cancer (GC), one of the most common malignant tumors in the world, exhibits a rapid
metastasis rate and causes high mortality. Diagnostic markers and potential therapeutic …

Chromatin has distinct three-dimensional (3D) architectures important in key biological
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …

Abstract Background Bronchial premalignant lesions (PMLs) are composed primarily of cells
resembling basal epithelial cells of the airways, which through poorly understood …

The TP63 is an indispensable transcription factor for development and homeostasis of
epithelia and its derived glandular tissue. It is also involved in female germline cell quality …

Transcriptional enhanced associate domain family members 1 to 4 (TEADs) are a family of
four transcription factors and the major transcriptional effectors of the Hippo pathway. In …

Skin cancers are by far the most frequently diagnosed human cancers. The closely related
transcriptional co‐regulator proteins YAP and TAZ (WWTR1) have emerged as important …

DNA damage-repair machinery participates in maintaining genomic integrity and affects
tumorigenesis. Molecular signatures based on DNA damage-repair-related genes (DRGs) …