Development of effective anti-influenza drugs: congeners and conjugates–a review
JJ Shie, JM Fang - Journal of Biomedical Science, 2019 - Springer
Influenza is a long-standing health problem. For treatment of seasonal flu and possible
pandemic infections, there is a need to develop new anti-influenza drugs that have good …
pandemic infections, there is a need to develop new anti-influenza drugs that have good …
Influenza neuraminidase: a druggable target for natural products
U Grienke, M Schmidtke, S von Grafenstein… - Natural product …, 2012 - pubs.rsc.org
Covering: 2000 to 2011 The imminent threat of influenza pandemics and repeatedly
reported emergence of new drug-resistant influenza virus strains demonstrate the urgent …
reported emergence of new drug-resistant influenza virus strains demonstrate the urgent …
Mesoscale all-atom influenza virus simulations suggest new substrate binding mechanism
Influenza virus circulates in human, avian, and swine hosts, causing seasonal epidemic and
occasional pandemic outbreaks. Influenza neuraminidase, a viral surface glycoprotein, has …
occasional pandemic outbreaks. Influenza neuraminidase, a viral surface glycoprotein, has …
[PDF][PDF] Prediction of protein structure and interaction by GALAXY protein modeling programs
The last century has witnessed remarkable advances in computational chemistry and
computational biology, and computational approaches are increasingly and more widely …
computational biology, and computational approaches are increasingly and more widely …
Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition
The 2009 H1N1 influenza pandemic (pH1N1) led to record sales of neuraminidase (NA)
inhibitors, which has contributed significantly to the recent increase in oseltamivir-resistant …
inhibitors, which has contributed significantly to the recent increase in oseltamivir-resistant …
Ensemble-based virtual screening reveals potential novel antiviral compounds for avian influenza neuraminidase
Avian influenza virus subtype H5N1 is a potential pandemic threat with human-adapted
strains resistant to antiviral drugs. Although virtual screening (VS) against a crystal or …
strains resistant to antiviral drugs. Although virtual screening (VS) against a crystal or …
Identification of chebulinic acid and chebulagic acid as novel influenza viral neuraminidase inhibitors
P Li, R Du, Y Wang, X Hou, L Wang, X Zhao… - Frontiers in …, 2020 - frontiersin.org
The influenza A virus (IAV) causes seasonal epidemics and occasional but devastating
pandemics, which are of a major public health concern. Although several antiviral drugs are …
pandemics, which are of a major public health concern. Although several antiviral drugs are …
Structural and functional characterization of neuraminidase-like molecule N10 derived from bat influenza A virus
Q Li, X Sun, Z Li, Y Liu, CJ Vavricka… - Proceedings of the …, 2012 - National Acad Sciences
The recent discovery of the unique genome of influenza virus H17N10 in bats raises
considerable doubt about the origin and evolution of influenza A viruses. It also identifies a …
considerable doubt about the origin and evolution of influenza A viruses. It also identifies a …
[HTML][HTML] New small-molecule drug design strategies for fighting resistant influenza A
Z Shen, K Lou, W Wang - Acta Pharmaceutica Sinica B, 2015 - Elsevier
Influenza A virus is the major cause of seasonal or pandemic flu worldwide. Two main
treatment strategies–vaccination and small molecule anti-influenza drugs are currently …
treatment strategies–vaccination and small molecule anti-influenza drugs are currently …
Mechanism of 150-cavity formation in influenza neuraminidase
The recently discovered 150-cavity in the active site of group-1 influenza A neuraminidase
(NA) proteins provides a target for rational structure-based drug development to counter the …
(NA) proteins provides a target for rational structure-based drug development to counter the …