Precision RNA base editing with engineered and endogenous effectors

LS Pfeiffer, T Stafforst - Nature Biotechnology, 2023 - nature.com
RNA base editing refers to the rewriting of genetic information within an intact RNA molecule
and serves various functions, such as evasion of the endogenous immune system and …

[HTML][HTML] Genetic and epigenetic defects of the RNA modification machinery in cancer

I Orsolic, A Carrier, M Esteller - Trends in Genetics, 2023 - cell.com
Cancer was initially considered to be an exclusively genetic disease, but an interplay of
dysregulated genetic and epigenetic mechanisms is now known to contribute to the cancer …

Modular, programmable RNA sensing using ADAR editing in living cells

KE Kaseniit, N Katz, NS Kolber, CC Call… - Nature …, 2023 - nature.com
With the increasing availability of single-cell transcriptomes, RNA signatures offer a
promising basis for targeting living cells. Molecular RNA sensors would enable the study of …

[HTML][HTML] RNA editing in cancer progression

V Frezza, L Chellini, A Del Verme, MP Paronetto - Cancers, 2023 - mdpi.com
Simple Summary Recent evidence from whole-exome and whole-genome sequencing
approaches revealed a complex genomic landscape for many cancers. In addition to …

A comprehensive review of lncRNA CRNDE in cancer progression and pathology, with a specific glance at the epithelial-mesenchymal transition (EMT) process

SA Jasim, SIS Al-Hawary, A Hjazi, I Ahmad… - … -Research and Practice, 2024 - Elsevier
It has been suggested that the long non-coding RNAs (lncRNAs), such as colorectal
neoplasia differentially expressed (CRNDE), may contribute to the formation of human …

ADAR-Mediated A> I (G) RNA Editing in the Genotoxic Drug Response of Breast Cancer

YA Bernal, E Durán, I Solar… - … Journal of Molecular …, 2024 - pmc.ncbi.nlm.nih.gov
Epitranscriptomics is a field that delves into post-transcriptional changes. Among these
modifications, the conversion of adenosine to inosine, traduced as guanosine (A> I (G)), is …

Upregulation of ADAR promotes breast cancer progression and serves as a potential therapeutic target

X Li, G Sun, L Wu, G Sun, Y Cheng, J Tao… - Journal of …, 2021 - Wiley Online Library
Background. Breast cancer (BC) is the most common cause of cancer death worldwide, and
its incidence is increasing every year. This study aims to investigate the expression …

A selective androgen receptor modulator, S4, displays robust anti-cancer activity on hepatocellular cancer cells by negatively regulating PI3K/AKT/mTOR signalling …

M Yavuz, LS Takanlou, ÇB Avcı, T Demircan - Gene, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is a major global health problem that often correlates with
poor prognosis. Due to the insufficient therapy options with limited benefits, it is crucial to …

Dichotomous roles of ADAR1 in liver hepatocellular carcinoma and kidney renal cell carcinoma: unraveling the complex tumor microenvironment and prognostic …

JX Mao, JJ Li, XY Lu, HX Zhong, YY Zhao… - International …, 2024 - Elsevier
Background Adenosine deaminase acting on RNA 1 (ADAR1) is an RNA-editing enzyme
that significantly impacts cancer progression and various biological processes. The …

Single-cell and genetic multi-omics analysis combined with experiments confirmed the signature and potential targets of cuproptosis in hepatocellular carcinoma

F Cao, Y Qi, W Wu, X Li, C Yang - Frontiers in Cell and …, 2023 - frontiersin.org
Background: Cuproptosis, as a recently discovered type of programmed cell death, occupies
a very important role in hepatocellular carcinoma (HCC) and provides new methods for …