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Precision RNA base editing with engineered and endogenous effectors
LS Pfeiffer, T Stafforst - Nature Biotechnology, 2023 - nature.com
RNA base editing refers to the rewriting of genetic information within an intact RNA molecule
and serves various functions, such as evasion of the endogenous immune system and …
and serves various functions, such as evasion of the endogenous immune system and …
[HTML][HTML] Genetic and epigenetic defects of the RNA modification machinery in cancer
I Orsolic, A Carrier, M Esteller - Trends in Genetics, 2023 - cell.com
Cancer was initially considered to be an exclusively genetic disease, but an interplay of
dysregulated genetic and epigenetic mechanisms is now known to contribute to the cancer …
dysregulated genetic and epigenetic mechanisms is now known to contribute to the cancer …
Modular, programmable RNA sensing using ADAR editing in living cells
With the increasing availability of single-cell transcriptomes, RNA signatures offer a
promising basis for targeting living cells. Molecular RNA sensors would enable the study of …
promising basis for targeting living cells. Molecular RNA sensors would enable the study of …
[HTML][HTML] RNA editing in cancer progression
V Frezza, L Chellini, A Del Verme, MP Paronetto - Cancers, 2023 - mdpi.com
Simple Summary Recent evidence from whole-exome and whole-genome sequencing
approaches revealed a complex genomic landscape for many cancers. In addition to …
approaches revealed a complex genomic landscape for many cancers. In addition to …
A comprehensive review of lncRNA CRNDE in cancer progression and pathology, with a specific glance at the epithelial-mesenchymal transition (EMT) process
It has been suggested that the long non-coding RNAs (lncRNAs), such as colorectal
neoplasia differentially expressed (CRNDE), may contribute to the formation of human …
neoplasia differentially expressed (CRNDE), may contribute to the formation of human …
ADAR-Mediated A> I (G) RNA Editing in the Genotoxic Drug Response of Breast Cancer
YA Bernal, E Durán, I Solar… - … Journal of Molecular …, 2024 - pmc.ncbi.nlm.nih.gov
Epitranscriptomics is a field that delves into post-transcriptional changes. Among these
modifications, the conversion of adenosine to inosine, traduced as guanosine (A> I (G)), is …
modifications, the conversion of adenosine to inosine, traduced as guanosine (A> I (G)), is …
Upregulation of ADAR promotes breast cancer progression and serves as a potential therapeutic target
X Li, G Sun, L Wu, G Sun, Y Cheng, J Tao… - Journal of …, 2021 - Wiley Online Library
Background. Breast cancer (BC) is the most common cause of cancer death worldwide, and
its incidence is increasing every year. This study aims to investigate the expression …
its incidence is increasing every year. This study aims to investigate the expression …
A selective androgen receptor modulator, S4, displays robust anti-cancer activity on hepatocellular cancer cells by negatively regulating PI3K/AKT/mTOR signalling …
Hepatocellular carcinoma (HCC) is a major global health problem that often correlates with
poor prognosis. Due to the insufficient therapy options with limited benefits, it is crucial to …
poor prognosis. Due to the insufficient therapy options with limited benefits, it is crucial to …
Dichotomous roles of ADAR1 in liver hepatocellular carcinoma and kidney renal cell carcinoma: unraveling the complex tumor microenvironment and prognostic …
JX Mao, JJ Li, XY Lu, HX Zhong, YY Zhao… - International …, 2024 - Elsevier
Background Adenosine deaminase acting on RNA 1 (ADAR1) is an RNA-editing enzyme
that significantly impacts cancer progression and various biological processes. The …
that significantly impacts cancer progression and various biological processes. The …
Single-cell and genetic multi-omics analysis combined with experiments confirmed the signature and potential targets of cuproptosis in hepatocellular carcinoma
F Cao, Y Qi, W Wu, X Li, C Yang - Frontiers in Cell and …, 2023 - frontiersin.org
Background: Cuproptosis, as a recently discovered type of programmed cell death, occupies
a very important role in hepatocellular carcinoma (HCC) and provides new methods for …
a very important role in hepatocellular carcinoma (HCC) and provides new methods for …