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Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms
Terpenoids represent a diverse class of molecules that provide a wealth of opportunities to
address many human health and societal issues. The expansive array of structures and …
address many human health and societal issues. The expansive array of structures and …
Biosynthesis of plant isoprenoids: perspectives for microbial engineering
J Kirby, JD Keasling - Annual review of plant biology, 2009 - annualreviews.org
Isoprenoids are a large and highly diverse group of natural products with many functions in
plant primary and secondary metabolism. Isoprenoids are synthesized from common prenyl …
plant primary and secondary metabolism. Isoprenoids are synthesized from common prenyl …
Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli
Taxol (paclitaxel) is a potent anticancer drug first isolated from the Taxus brevifolia Pacific
yew tree. Currently, cost-efficient production of Taxol and its analogs remains limited. Here …
yew tree. Currently, cost-efficient production of Taxol and its analogs remains limited. Here …
Programming cells by multiplex genome engineering and accelerated evolution
The breadth of genomic diversity found among organisms in nature allows populations to
adapt to diverse environments,. However, genomic diversity is difficult to generate in the …
adapt to diverse environments,. However, genomic diversity is difficult to generate in the …
Lycopene overproduction in Saccharomyces cerevisiae through combining pathway engineering with host engineering
Y Chen, W **ao, Y Wang, H Liu, X Li, Y Yuan - Microbial cell factories, 2016 - Springer
Background Microbial production of lycopene, a commercially and medically important
compound, has received increasing concern in recent years. Saccharomyces cerevisiae is …
compound, has received increasing concern in recent years. Saccharomyces cerevisiae is …
Metabolic engineering of Escherichia coli: a sustainable industrial platform for bio-based chemical production
In order to decrease carbon emissions and negative environmental impacts of various
pollutants, more bulk and/or fine chemicals are produced by bioprocesses, replacing the …
pollutants, more bulk and/or fine chemicals are produced by bioprocesses, replacing the …
[HTML][HTML] Modular engineering for microbial production of carotenoids
C Li, CA Swofford, AJ Sinskey - Metabolic Engineering Communications, 2020 - Elsevier
There is an increasing demand for carotenoids due to their applications in the food, flavor,
pharmaceutical and feed industries, however, the extraction and synthesis of these …
pharmaceutical and feed industries, however, the extraction and synthesis of these …
Selection and optimization of microbial hosts for biofuels production
CR Fischer, D Klein-Marcuschamer… - Metabolic …, 2008 - Elsevier
Currently, the predominant microbially produced biofuel is starch-or sugar-derived ethanol.
However, ethanol is not an ideal fuel molecule, and lignocellulosic feedstocks are …
However, ethanol is not an ideal fuel molecule, and lignocellulosic feedstocks are …
Advances in the synthesis of three typical tetraterpenoids including β-carotene, lycopene and astaxanthin
Y **g, Y Wang, D Zhou, J Wang, J Li, J Sun… - Biotechnology …, 2022 - Elsevier
Carotenoids are natural pigments that widely exist in nature. Due to their excellent
antioxidant, anticancer and anti-inflammatory properties, carotenoids are commonly used in …
antioxidant, anticancer and anti-inflammatory properties, carotenoids are commonly used in …
In Silico Identification of Gene Amplification Targets for Improvement of Lycopene Production
The identification of genes to be deleted or amplified is an essential step in metabolic
engineering for strain improvement toward the enhanced production of desired bioproducts …
engineering for strain improvement toward the enhanced production of desired bioproducts …