Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms

PK Ajikumar, K Tyo, S Carlsen, O Mucha… - Molecular …, 2008 - ACS Publications
Terpenoids represent a diverse class of molecules that provide a wealth of opportunities to
address many human health and societal issues. The expansive array of structures and …

Biosynthesis of plant isoprenoids: perspectives for microbial engineering

J Kirby, JD Keasling - Annual review of plant biology, 2009 - annualreviews.org
Isoprenoids are a large and highly diverse group of natural products with many functions in
plant primary and secondary metabolism. Isoprenoids are synthesized from common prenyl …

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

PK Ajikumar, WH **ao, KEJ Tyo, Y Wang, F Simeon… - Science, 2010 - science.org
Taxol (paclitaxel) is a potent anticancer drug first isolated from the Taxus brevifolia Pacific
yew tree. Currently, cost-efficient production of Taxol and its analogs remains limited. Here …

Programming cells by multiplex genome engineering and accelerated evolution

HH Wang, FJ Isaacs, PA Carr, ZZ Sun, G Xu, CR Forest… - Nature, 2009 - nature.com
The breadth of genomic diversity found among organisms in nature allows populations to
adapt to diverse environments,. However, genomic diversity is difficult to generate in the …

Lycopene overproduction in Saccharomyces cerevisiae through combining pathway engineering with host engineering

Y Chen, W **ao, Y Wang, H Liu, X Li, Y Yuan - Microbial cell factories, 2016 - Springer
Background Microbial production of lycopene, a commercially and medically important
compound, has received increasing concern in recent years. Saccharomyces cerevisiae is …

Metabolic engineering of Escherichia coli: a sustainable industrial platform for bio-based chemical production

X Chen, L Zhou, K Tian, A Kumar, S Singh… - Biotechnology …, 2013 - Elsevier
In order to decrease carbon emissions and negative environmental impacts of various
pollutants, more bulk and/or fine chemicals are produced by bioprocesses, replacing the …

[HTML][HTML] Modular engineering for microbial production of carotenoids

C Li, CA Swofford, AJ Sinskey - Metabolic Engineering Communications, 2020 - Elsevier
There is an increasing demand for carotenoids due to their applications in the food, flavor,
pharmaceutical and feed industries, however, the extraction and synthesis of these …

Selection and optimization of microbial hosts for biofuels production

CR Fischer, D Klein-Marcuschamer… - Metabolic …, 2008 - Elsevier
Currently, the predominant microbially produced biofuel is starch-or sugar-derived ethanol.
However, ethanol is not an ideal fuel molecule, and lignocellulosic feedstocks are …

Advances in the synthesis of three typical tetraterpenoids including β-carotene, lycopene and astaxanthin

Y **g, Y Wang, D Zhou, J Wang, J Li, J Sun… - Biotechnology …, 2022 - Elsevier
Carotenoids are natural pigments that widely exist in nature. Due to their excellent
antioxidant, anticancer and anti-inflammatory properties, carotenoids are commonly used in …

In Silico Identification of Gene Amplification Targets for Improvement of Lycopene Production

HS Choi, SY Lee, TY Kim, HM Woo - Applied and environmental …, 2010 - journals.asm.org
The identification of genes to be deleted or amplified is an essential step in metabolic
engineering for strain improvement toward the enhanced production of desired bioproducts …