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Cancer stem cells: Advances in knowledge and implications for cancer therapy
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …
Notch signaling pathway in cancer: from mechanistic insights to targeted therapies
Q Shi, C Xue, Y Zeng, X Yuan, Q Chu, S Jiang… - … and Targeted Therapy, 2024 - nature.com
Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue
homeostasis across metazoans, is highly conserved throughout evolution. The Notch …
homeostasis across metazoans, is highly conserved throughout evolution. The Notch …
Targeting epigenetic regulators to overcome drug resistance in cancers
Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …
regulation is a heritable change in gene expressions independent of nucleotide sequence …
Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy
M Chehelgerdi, F Behdarvand Dehkordi… - Molecular cancer, 2023 - Springer
The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …
Tumor microenvironment signaling and therapeutics in cancer progression
Tumor development and metastasis are facilitated by the complex interactions between
cancer cells and their microenvironment, which comprises stromal cells and extracellular …
cancer cells and their microenvironment, which comprises stromal cells and extracellular …
Cross-talk between cancer stem cells and immune cells: potential therapeutic targets in the tumor immune microenvironment
B Wu, X Shi, M Jiang, H Liu - Molecular Cancer, 2023 - Springer
Ongoing research has revealed that the existence of cancer stem cells (CSCs) is one of the
biggest obstacles in the current cancer therapy. CSCs make an influential function in tumor …
biggest obstacles in the current cancer therapy. CSCs make an influential function in tumor …
Altered metabolism in cancer: Insights into energy pathways and therapeutic targets
Cancer cells undergo significant metabolic reprogramming to support their rapid growth and
survival. This study examines important metabolic pathways like glycolysis, oxidative …
survival. This study examines important metabolic pathways like glycolysis, oxidative …
[HTML][HTML] SCD1 is the critical signaling hub to mediate metabolic diseases: mechanism and the development of its inhibitors
Q Sun, X **ng, H Wang, K Wan, R Fan, C Liu… - Biomedicine & …, 2024 - Elsevier
Metabolic diseases, featured with dysregulated energy homeostasis, have become major
global health challenges. Patients with metabolic diseases have high probability to manifest …
global health challenges. Patients with metabolic diseases have high probability to manifest …
Uncovering the complex role of interferon-gamma in suppressing type 2 immunity to cancer
Cancer involves cells' abnormal growth and ability to invade or metastasize to different body
parts. Cancerous cells can divide uncontrollably and spread to other areas through the …
parts. Cancerous cells can divide uncontrollably and spread to other areas through the …
Cell plasticity, senescence, and quiescence in cancer stem cells: Biological and therapeutic implications
Cancer stem cells (CSCs) are a distinct population of cells within tumors with capabilities of
self-renewal and tumorigenicity. CSCs play a pivotal role in cancer progression, metastasis …
self-renewal and tumorigenicity. CSCs play a pivotal role in cancer progression, metastasis …