The emerging roles of circRNAs in cancer and oncology

LS Kristensen, T Jakobsen, H Hager… - Nature reviews Clinical …, 2022 - nature.com
Over the past decade, circular RNAs (circRNAs) have emerged as a large class of primarily
non-coding RNA molecules, many of which have key roles in cancer development and …

Circular RNA in cancer

VM Conn, AM Chinnaiyan, SJ Conn - Nature Reviews Cancer, 2024 - nature.com
Over the past decade, circular RNA (circRNA) research has evolved into a bona fide
research field shedding light on the functional consequence of this unique family of RNA …

CircAtlas: an integrated resource of one million highly accurate circular RNAs from 1070 vertebrate transcriptomes

W Wu, P Ji, F Zhao - Genome biology, 2020 - Springer
Existing circular RNA (circRNA) databases have become essential for transcriptomics.
However, most are unsuitable for mining in-depth information for candidate circRNA …

Circular RNAs and complex diseases: from experimental results to computational models

CC Wang, CD Han, Q Zhao, X Chen - Briefings in bioinformatics, 2021 - academic.oup.com
Circular RNAs (circRNAs) are a class of single-stranded, covalently closed RNA molecules
with a variety of biological functions. Studies have shown that circRNAs are involved in a …

Comprehensive profiling of circular RNAs with nanopore sequencing and CIRI-long

J Zhang, L Hou, Z Zuo, P Ji, X Zhang, Y Xue… - Nature …, 2021 - nature.com
Reconstructing the sequence of circular RNAs (circRNAs) from short RNA sequencing reads
has proved challenging given the similarity of circRNAs and their corresponding linear …

Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets

T Loganathan, GP Doss C - Functional & integrative genomics, 2023 - Springer
Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …

Transcriptional landscape and clinical utility of enhancer RNAs for eRNA-targeted therapy in cancer

Z Zhang, JH Lee, H Ruan, Y Ye, J Krakowiak… - Nature …, 2019 - nature.com
Enhancer RNA (eRNA) is a type of noncoding RNA transcribed from the enhancer. Although
critical roles of eRNA in gene transcription control have been increasingly realized, the …

Circular RNA translation: novel protein isoforms and clinical significance

S Wen, J Qadir, BB Yang - Trends in molecular medicine, 2022 - cell.com
In recent years, significant attention has focused on circular RNA (circRNA) translation to
determine its clinical significance. Cap-independent translation of circRNAs driven by an …

Deep learning and ensemble deep learning for circRNA-RBP interaction prediction in the last decade: A review

D Lasantha, S Vidanagamachchi… - … Applications of Artificial …, 2023 - Elsevier
Circular ribonucleic acids (circRNAs) are widely expressed in cells and tissues and play vital
roles in cellular physiological processes. Their expressions are associated with …

[HTML][HTML] Circular RNAs in cancer: limitations in functional studies and diagnostic potential

F Li, Q Yang, AT He, BB Yang - Seminars in cancer biology, 2021 - Elsevier
Circular RNAs (circRNAs) are a large class of noncoding RNAs, generated from a process
called back-splicing, that possess critical regulatory functions in many cellular events. A …