Curved membranes are key features of intracellular organelles, and their generation
involves dynamic protein complexes. Here we describe the fundamental mechanisms such …

Cholesterol is an essential structural component in the cell membranes of most vertebrates.
The biophysical properties of cholesterol and the enzymology of cholesterol metabolism …

Cellular versatility depends on accurate trafficking of diverse proteins to their organellar
destinations. For the secretory pathway (followed by approximately 30% of all proteins), the …

Several proteins at endoplasmic reticulum (ER)-Golgi membrane contact sites contain a PH
domain that interacts with the Golgi phosphoinositide PI (4) P, a FFAT motif that interacts …

Abstract Knowledge on the distribution and dynamics of glycosylation enzymes in the Golgi
is essential for better understanding this modification. Here, using a combination of …

The two mannose 6-phosphate (M6P) receptors were identified because of their ability to
bind M6P-containing soluble acid hydrolases in the Golgi and transport them to the …

The importance of curvature as a structural feature of biological membranes has been
recognized for many years and has fascinated scientists from a wide range of different …

Synthesis and sorting of lipids are essential for membrane biogenesis; however, the
mechanisms underlying the transport of membrane lipids remain little understood. Ceramide …

The endoplasmic reticulum (ER) is a large, continuous membrane-bound organelle
comprised of functionally and structurally distinct domains including the nuclear envelope …

Collagen fibrils in the extracellular matrix allow connective tissues such as tendon, skin and
bone to withstand tensile forces. The fibrils are indeterminate in length, insoluble and form …