Gastrointestinal stromal tumours (GIST) have an incidence of~ 1.2 per 105 individuals per
year in most countries. Around 80% of GIST have varying molecular changes, predominantly …

When gastrointestinal stromal tumour (GIST), the most common form of sarcoma, was first
recognized as a distinct pathological entity in the 1990s, patients with advanced-stage …

Gastrointestinal stromal tumors (GIST) are the most common type of soft tissue sarcoma that
occur throughout the gastrointestinal tract. Most of these tumors are caused by oncogenic …

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the
gastrointestinal tract. The majority of GISTs harbor gain of function mutations in either KIT or …

FGFRs are receptor tyrosine kinases with a role in several biological processes, such as the
regulation of development and tissue repair. However, alterations in FGFRs 1–4, such as …

Purpose Fusions that involve neurotrophic-tropomyosin receptor kinase (NTRK) genes are
known drivers of oncogenesis. Therapies that target these ultra-rare, constitutionally active …

The tropomyosin receptor kinase (TRK) family of receptor tyrosine kinases are encoded by
NTRK genes and have a role in the development and normal functioning of the nervous …

Chromosomal rearrangements involving the NTRK1, NTRK2, and NTRK3 genes (NTRK
genes), which encode the high-affinity nerve growth factor receptor (TRKA), brain-derived …

overview Gastrointestinal stromal tumor (GIST) is the most common malignant neoplasm of
mesenchymal origin and a compelling clinical and biologic model for the rational …

The neurotrophic tyrosine receptor kinase (NTRK) gene family encodes three tropomyosin
receptor kinases (TRKA, TRKB, TRKC) that contribute to central and peripheral nervous …