Cancer development requires the acquisition of several capabilities that include increased
replicative potential, anchorage and growth-factor independence, evasion of apoptosis …

The formation of epithelial cell barriers results from the defined spatiotemporal differentiation
of stem cells into a specialized and polarized epithelium, a process termed mesenchymal …

Purpose: The presence of similar histologic subtypes of epithelial ovarian and endometrial
cancers has long been noted, although the relevance of this finding to pathogenesis and …

To identify the major tumor suppressor gene (TSG) loci involved in the pathogenesis of lung
cancer, we have conducted a high-resolution (10 cM), genome-wide search of loss of …

Adherens junctions (AJs) are essential for the maintenance of epithelial homeostasis and a
key factor in the regulation of cell migration and tumor progression. AJs maintain cell-cell …

Using a genetic complementation approach we have identified disabled‐2 (Dab2), a
structural homolog of the Dab1 adaptor molecule, as a critical link between the transforming …

Disabled‐2 (Dab2) is a widely expressed relative of Disabled‐1, a neuron‐specific signal‐
transduction protein that binds to and receives signals from members of the low‐density …

Background & Objectives: Chromatin structure is the single most important feature that
distinguishes a cancer cell from a normal cell histologically. Chromatin remodeling proteins …

Bcl-2 and p53 gene products have been both linked to cell death by apoptosis. In the
present study, we examined the relationship of Bcl-2 and p53 protein expression, p53 …

Abstract The Disabled‐2 (Dab2) gene has been proposed to act as a tumor suppressor. Cell
culture studies have implicated Dab2 in signal transduction by mitogens, TGFβ and …