Advances in hydrogen/deuterium exchange mass spectrometry and the pursuit of challenging biological systems
Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …
a widespread tool for structural analysis across academia and the biopharmaceutical …
[HTML][HTML] Unraveling protein's structural dynamics: from configurational dynamics to ensemble switching guides functional mesoscale assemblies
Highlights•The unanimated visualization of proteins must be revisited to highlights the
relevance of structural dynamics•A combination of single-molecule multiparameter …
relevance of structural dynamics•A combination of single-molecule multiparameter …
Computational modeling of molecular structures guided by hydrogen-exchange data
Data produced by hydrogen-exchange monitoring experiments have been used in structural
studies of molecules for several decades. Despite uncertainties about the structural …
studies of molecules for several decades. Despite uncertainties about the structural …
Integrating single-molecule spectroscopy and simulations for the study of intrinsically disordered proteins
Over the last two decades, intrinsically disordered proteins and protein regions (IDRs) have
emerged from a niche corner of biophysics to be recognized as essential drivers of cellular …
emerged from a niche corner of biophysics to be recognized as essential drivers of cellular …
DNA facilitates heterodimerization between human transcription factors FoxP1 and FoxP2 by increasing their conformational flexibility
Transcription factors regulate gene expression by binding to DNA. They have disordered
regions and specific DNA-binding domains. Binding to DNA causes structural changes …
regions and specific DNA-binding domains. Binding to DNA causes structural changes …
Integrative structural dynamics probing of the conformational heterogeneity in synaptosomal-associated protein 25
Summary SNAP-25 (synaptosomal-associated protein of 25 kDa) is a prototypical
intrinsically disordered protein (IDP) that is unstructured by itself but forms coiled-coil helices …
intrinsically disordered protein (IDP) that is unstructured by itself but forms coiled-coil helices …
[HTML][HTML] Domain tethering impacts dimerization and DNA-mediated allostery in the human transcription factor FoxP1
P Cruz, N Paredes, I Asela, N Kolimi… - The Journal of …, 2023 - pubs.aip.org
Transcription factors are multidomain proteins with specific DNA binding and regulatory
domains. In the human FoxP subfamily (FoxP1, FoxP2, FoxP3, and FoxP4) of transcription …
domains. In the human FoxP subfamily (FoxP1, FoxP2, FoxP3, and FoxP4) of transcription …
Proteogenomic Approaches to Understand Gene Mutations and Protein Structural Alterations in Colon Cancer
S Sarkar - Physiologia, 2023 - mdpi.com
With colon cancer being one of the deadliest and most common cancers, understanding the
mechanisms behind colon cancer is crucial in improving therapies. One of the newest …
mechanisms behind colon cancer is crucial in improving therapies. One of the newest …
DNA controls the dimerization of the human FoxP1 forkhead domain
Transcription factors (TFs) regulate gene expression by binding to specific DNA sequences
and gating access to genes. Even when the binding of TFs and their cofactors to DNA is …
and gating access to genes. Even when the binding of TFs and their cofactors to DNA is …
Dissecting the structural and functional consequences of the evolutionary proline–glycine deletion in the wing 1 region of the forkhead domain of human FoxP1
S Tamarín, P Galaz‐Davison… - FEBS …, 2024 - Wiley Online Library
The human FoxP transcription factors dimerize via three‐dimensional domain swap**, a
unique feature among the human Fox family, as result of evolutionary sequence adaptations …
unique feature among the human Fox family, as result of evolutionary sequence adaptations …