Neurotrophins are a family of closely related proteins that were identified initially as survival
factors for sensory and sympathetic neurons, and have since been shown to control many …

Understanding the mechanisms that underlie learning is one of the most fascinating and
central aims of neurobiological research. Hippocampal long-term potentiation (LTP) is …

Neurotrophins, including brain-derived neurotrophic factor (BDNF), are expressed in the
hippocampus, as well as their precursors, the pro-neurotrophins. The neurotrophins signal …

Neural stem cells (NSCs) are controlled by diffusible factors. The transcription factor Sox2 is
expressed by NSCs and Sox2 mutations in humans cause defects in the brain and, in …

The neurotrophic tropomyosin receptor kinase (NTRK) genes (NTRK1, NTRK2, and NTRK3)
code for three transmembrane high-affinity tyrosine-kinase receptors for nerve growth factors …

Increasing evidence indicates that development of embryonic central nervous system
precursors is tightly regulated by extrinsic cues located in the local environment. Here, we …

SOX2 is a transcription factor conserved throughout vertebrate evolution, whose expression
marks the central nervous system from the earliest developmental stages. In humans, SOX2 …

Support of ageing neurons by endogenous neurotrophic factors such as glial cell line–
derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) may …

The neurotrophin brain-derived neurotrophic factor (BDNF) has been implicated in
regulating CNS myelination. BDNF mutant mice exhibit a hypomyelinating phenotype, and …

Previous work in culture has shown that basal forebrain (BF) oligodendrocyte (OLG) lineage
cells respond to BDNF by increasing DNA synthesis and differentiation. Further, in the BF in …