Proper vertebrae formation relies on a tissue-wide oscillator called the segmentation clock.
Individual cellular oscillators in the presomitic mesoderm are modulated by intercellular …

The mammalian cerebral cortex is the pinnacle of brain evolution, reaching its maximum
complexity in terms of neuron number, diversity and functional circuitry. The emergence of …

Randomness characterizes many processes in nature, and therefore its importance cannot
be overstated. In the present study, we investigate examples of randomness found in various …

Temporal control is central to deploy and coordinate genetic programs during development.
At present, there is limited understanding of the molecular mechanisms that govern the …

Oscillatory phenomena play widespread roles in the control of biological systems. In D.
discoideum, oscillatory cyclic adenosine monophosphate (cAMP) signaling drives collective …

Periodic gene expression dynamics are key to cell and organism physiology. Studies of
oscillatory expression have focused on networks with intuitive regulatory negative feedback …

Exercise has been recognized as a beneficial factor for cognitive health, particularly in
relation to the hippocampus, a vital brain region responsible for learning and memory …

During embryogenesis cells make fate decisions within complex tissue environments. The
levels and dynamics of transcription factor expression regulate these decisions. Here, we …

Taming cell-to-cell variability in gene expression is critical for precise pattern formation
during embryonic development. To investigate the source and buffering mechanism of …

Canonical Notch signaling has diverse functions during nervous system development and is
critical for neural progenitor self-renewal, timing of differentiation and specification of various …