Neurotrophin regulation of neural circuit development and function
H Park, M Poo - Nature Reviews Neuroscience, 2013 - nature.com
Brain-derived neurotrophic factor (BDNF)—a member of a small family of secreted proteins
that includes nerve growth factor, neurotrophin 3 and neurotrophin 4—has emerged as a …
that includes nerve growth factor, neurotrophin 3 and neurotrophin 4—has emerged as a …
The sympathetic nervous system in development and disease
E Scott-Solomon, E Boehm, R Kuruvilla - Nature Reviews …, 2021 - nature.com
The sympathetic nervous system prepares the body for 'fight or flight'responses and
maintains homeostasis during daily activities such as exercise, eating a meal or regulation …
maintains homeostasis during daily activities such as exercise, eating a meal or regulation …
The struggle to make CNS axons regenerate: why has it been so difficult?
JW Fawcett - Neurochemical research, 2020 - Springer
Axon regeneration in the CNS is inhibited by many extrinsic and intrinsic factors. Because
these act in parallel, no single intervention has been sufficient to enable full regeneration of …
these act in parallel, no single intervention has been sufficient to enable full regeneration of …
Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer's Disease
DJ Colacurcio, A Pensalfini, Y Jiang… - Free Radical Biology and …, 2018 - Elsevier
Individuals with Down syndrome (DS) have an increased risk of early-onset Alzheimer's
Disease (AD), largely owing to a triplication of the APP gene, located on chromosome 21. In …
Disease (AD), largely owing to a triplication of the APP gene, located on chromosome 21. In …
Cellular and molecular mechanisms regulating neuronal growth by brain‐derived neurotrophic factor
Brain‐derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic
and axonal growth during development and maintenance of the mature nervous system; …
and axonal growth during development and maintenance of the mature nervous system; …
Compartmentalized signaling in neurons: from cell biology to neuroscience
Neurons are the largest known cells, with complex and highly polarized morphologies. As
such, neuronal signaling is highly compartmentalized, requiring sophisticated transfer …
such, neuronal signaling is highly compartmentalized, requiring sophisticated transfer …
Integrins promote axonal regeneration after injury of the nervous system
Integrins are cell surface receptors that form the link between extracellular matrix molecules
of the cell environment and internal cell signalling and the cytoskeleton. They are involved in …
of the cell environment and internal cell signalling and the cytoskeleton. They are involved in …
Shortcut approaches to substance delivery into the brain based on intranasal administration using nanodelivery strategies for insulin
T Tashima - Molecules, 2020 - mdpi.com
The direct delivery of central nervous system (CNS) drugs into the brain after administration
is an ideal concept due to its effectiveness and non-toxicity. However, the blood–brain …
is an ideal concept due to its effectiveness and non-toxicity. However, the blood–brain …
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling
Binding of target-derived neurotrophins to Trk receptors at nerve terminals is required to
stimulate neuronal survival, differentiation, innervation and synaptic plasticity. The distance …
stimulate neuronal survival, differentiation, innervation and synaptic plasticity. The distance …
Mechanisms of neurotrophin trafficking via Trk receptors
E Scott-Solomon, R Kuruvilla - Molecular and Cellular Neuroscience, 2018 - Elsevier
In neurons, long-distance communication between axon terminals and cell bodies is a
critical determinant in establishing and maintaining neural circuits. Neurotrophins are …
critical determinant in establishing and maintaining neural circuits. Neurotrophins are …