Breast cancer (BC) is the most commonly diagnosed cancer in women worldwide. 1 It is a
heterogeneous disease, comprising distinct biologic entities with different prognosis and …

HER2 status in breast cancer is assessed to select patients eligible for targeted therapy with
anti-HER2 therapies. According to the American Society of Clinical Oncology (ASCO) and …

Background Treatment options for women presenting with triple negative breast cancer
(TNBC) are limited due to the lack of a therapeutic target and as a result, are managed with …

Human breast tumours are diverse in their natural history and in their responsiveness to
treatments. Variation in transcriptional programs accounts for much of the biological diversity …

Many genes and signalling pathways controlling cell proliferation, death and differentiation,
as well as genomic integrity, are involved in cancer development. New techniques, such as …

Sample damage by X-rays and other radiation limits the resolution of structural studies on
non-repetitive and non-reproducible structures such as individual biomolecules or cells …

We describe a new method for relative quantification of 40 different DNA sequences in an
easy to perform reaction requiring only 20 ng of human DNA. Applications shown of this …

Gastric cancer is the second leading cause of cancer mortality in the world and its
management, especially in advanced stages, has evolved relatively little. In particular, no …

One of the benefits of Digital PCR (dPCR) is the potential for unparalleled precision
enabling smaller fold change measurements. An example of an assessment that could …

Human epidermal growth factor receptor-2 (HER2/erbB-2) belongs to a family of four
transmembrane receptors involved in signal transduction pathways that regulate cell growth …