Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions

J Ma, Y Li, X Yang, K Liu, X Zhang, X Zuo… - Signal transduction and …, 2023 - nature.com
Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

[HTML][HTML] Gut microbiota in hypertension and atherosclerosis: a review

BJH Verhaar, A Prodan, M Nieuwdorp, M Muller - Nutrients, 2020 - mdpi.com
Gut microbiota and its metabolites such as short chain fatty acids (SCFA),
lipopolysaccharides (LPS), and trimethylamine-N-oxide (TMAO) impact cardiovascular …

The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease

T Yang, EM Richards, CJ Pepine… - Nature Reviews …, 2018 - nature.com
Crosstalk between the gut microbiota and the host has attracted considerable attention
owing to its involvement in diverse diseases. Chronic kidney disease (CKD) is commonly …

Gut dysbiosis is linked to hypertension

T Yang, MM Santisteban, V Rodriguez, E Li… - …, 2015 - ahajournals.org
Emerging evidence suggests that gut microbiota is critical in the maintenance of
physiological homeostasis. This study was designed to test the hypothesis that dysbiosis in …

Hypertension-linked pathophysiological alterations in the gut

MM Santisteban, Y Qi, J Zubcevic, S Kim… - Circulation …, 2017 - ahajournals.org
Rationale: Sympathetic nervous system control of inflammation plays a central role in
hypertension. The gut receives significant sympathetic innervation, is densely populated …

Aging, arterial stiffness, and hypertension

Z Sun - Hypertension, 2015 - ahajournals.org
Arterial stiffening, at least, reflects gradual fragmentation and loss of elastin fibers and
accumulation of stiffer collagen fibers in the media of large arteries and occurs …

Gut microbiome and neuroinflammation in hypertension

EM Richards, J Li, BR Stevens, CJ Pepine… - Circulation …, 2022 - ahajournals.org
Hypertension is a worldwide problem with major impacts on health including morbidity and
mortality, as well as consumption of health care resources. Nearly 50% of American adults …

Critical role of the interaction gut microbiota–sympathetic nervous system in the regulation of blood pressure

M Toral, I Robles-Vera, N De la Visitacion… - Frontiers in …, 2019 - frontiersin.org
Association between gut dysbiosis and neurogenic diseases, such as hypertension, has
been described. The aim of this study was to investigate whether changes in the gut …

[HTML][HTML] Gut microbiota-derived short-chain fatty acids and hypertension: Mechanism and treatment

F Yang, H Chen, Y Gao, N An, X Li, X Pan… - Biomedicine & …, 2020 - Elsevier
Hypertension (HTN) is an growing emerging health issue around across the world. In recent
years, increasing attention has been paid to the role of dysbacteriosis in HTN and its …

Impaired autonomic nervous system-microbiome circuit in hypertension: a premise for hypertension therapy

J Zubcevic, EM Richards, T Yang, S Kim… - Circulation …, 2019 - ahajournals.org
Hypertension affects an estimated 103 million Americans, yet gaps in knowledge continue to
limit its successful management. Rapidly emerging evidence is linking gut dysbiosis to many …