Targets, models and challenges in osteoarthritis research
S Thysen, FP Luyten… - Disease models & …, 2015 - journals.biologists.com
Osteoarthritis is a chronic degenerative disorder of the joint and represents one of the most
common diseases worldwide. Its prevalence and severity are increasing owing to aging of …
common diseases worldwide. Its prevalence and severity are increasing owing to aging of …
Evolutionary perspectives on human height variation
Human height is a highly variable trait, both within and between populations, has a high
heritability, and influences the manner in which people behave and are treated in society …
heritability, and influences the manner in which people behave and are treated in society …
Ancestry-inclusive dog genomics challenges popular breed stereotypes
Behavioral genetics in dogs has focused on modern breeds, which are isolated subgroups
with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed …
with distinctive physical and, purportedly, behavioral characteristics. We interrogated breed …
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …
predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of …
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
Birth weight within the normal range is associated with a variety of adult-onset diseases, but
the mechanisms behind these associations are poorly understood. Previous genome-wide …
the mechanisms behind these associations are poorly understood. Previous genome-wide …
Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis
Adolescent idiopathic scoliosis (AIS) is the most common pediatric skeletal disease. We
previously reported a locus on chromosome 10q24. 31 associated with AIS susceptibility in …
previously reported a locus on chromosome 10q24. 31 associated with AIS susceptibility in …
Maternal ethanol consumption alters the epigenotype and the phenotype of offspring in a mouse model
Recent studies have shown that exposure to some nutritional supplements and chemicals in
utero can affect the epigenome of the develo** mouse embryo, resulting in adult disease …
utero can affect the epigenome of the develo** mouse embryo, resulting in adult disease …
Four loci explain 83% of size variation in the horse
Horse body size varies greatly due to intense selection within each breed. American
Miniatures are less than one meter tall at the withers while Shires and Percherons can …
Miniatures are less than one meter tall at the withers while Shires and Percherons can …
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity
The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both
the central onset of puberty and local growth factors. Although little is known about the …
the central onset of puberty and local growth factors. Although little is known about the …