Protein transmission in neurodegenerative disease
Most neurodegenerative diseases are characterized by the intracellular or extracellular
aggregation of misfolded proteins such as amyloid-β and tau in Alzheimer disease, α …
aggregation of misfolded proteins such as amyloid-β and tau in Alzheimer disease, α …
Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases
C Soto, S Pritzkow - Nature neuroscience, 2018 - nature.com
A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and
accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and …
accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and …
A new era for understanding amyloid structures and disease
The aggregation of proteins into amyloid fibrils and their deposition into plaques and
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …
Oxidative stress and beta amyloid in Alzheimer's disease. Which comes first: the chicken or the egg?
The pathogenesis of Alzheimer's disease involves β amyloid (Aβ) accumulation known to
induce synaptic dysfunction and neurodegeneration. The brain's vulnerability to oxidative …
induce synaptic dysfunction and neurodegeneration. The brain's vulnerability to oxidative …
Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases
M Jucker, LC Walker - Nature neuroscience, 2018 - nature.com
Many neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, are characterized by the progressive appearance of abnormal …
amyotrophic lateral sclerosis, are characterized by the progressive appearance of abnormal …
Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein
M Goedert - Science, 2015 - science.org
BACKGROUND Alzheimer's disease (AD) and Parkinson's disease (PD) are the most
common human neurodegenerative diseases. AD is primarily a dementing disease, and PD …
common human neurodegenerative diseases. AD is primarily a dementing disease, and PD …
Propagation of tau aggregates and neurodegeneration
A pathway from the natively unfolded microtubule-associated protein Tau to a highly
structured amyloid fibril underlies human Tauopathies. This ordered assembly causes …
structured amyloid fibril underlies human Tauopathies. This ordered assembly causes …
Alzheimer disease pathogenesis: insights from molecular and cellular biology studies of oligomeric Aβ and tau species
XQ Chen, WC Mobley - Frontiers in Neuroscience, 2019 - frontiersin.org
Alzheimer disease (AD) represents an oncoming epidemic that without an effective
treatment promises to exact extraordinary human and financial burdens. Studies of …
treatment promises to exact extraordinary human and financial burdens. Studies of …
A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Aβ oligomers from Alzheimer's brain
It is increasingly accepted that early cognitive impairment in Alzheimer's disease results in
considerable part from synaptic dysfunction caused by the accumulation of a range of …
considerable part from synaptic dysfunction caused by the accumulation of a range of …
Aβ (1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease
Increasing evidence has suggested that formation and propagation of misfolded aggregates
of 42-residue human amyloid β (Aβ (1–42)), rather than of the more abundant Aβ (1–40) …
of 42-residue human amyloid β (Aβ (1–42)), rather than of the more abundant Aβ (1–40) …