Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities
NG Frangogiannis - Molecular aspects of medicine, 2019 - Elsevier
Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …
Cardiomyocyte senescence and cellular communications within myocardial microenvironments
X Tang, PH Li, HZ Chen - Frontiers in Endocrinology, 2020 - frontiersin.org
Cardiovascular diseases have become the leading cause of human death. Aging is an
independent risk factor for cardiovascular diseases. Cardiac aging is associated with …
independent risk factor for cardiovascular diseases. Cardiac aging is associated with …
Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A
EJ Im, CH Lee, PG Moon, GG Rangaswamy… - Nature …, 2019 - nature.com
Inhibitors of the secretion of cancer exosomes, which promote cancer progression and
metastasis, may not only accelerate exosome biology research but also offer therapeutic …
metastasis, may not only accelerate exosome biology research but also offer therapeutic …
Mitophagy receptors and mediators: therapeutic targets in the management of cardiovascular ageing
A Ajoolabady, H Aslkhodapasandhokmabad… - Ageing Research …, 2020 - Elsevier
Mitophagy serves as a cardinal regulator in the maintenance of mitochondrial integrity,
function, and cardiovascular homeostasis, through the fine control and governance of …
function, and cardiovascular homeostasis, through the fine control and governance of …
Myocardial stress and autophagy: mechanisms and potential therapies
Autophagy is a ubiquitous cellular catabolic process responsive to energy stress. Research
over the past decade has revealed that cardiomyocyte autophagy is a prominent …
over the past decade has revealed that cardiomyocyte autophagy is a prominent …
The role of exercise in cardiac aging: from physiology to molecular mechanisms
Aging induces structural and functional changes in the heart that are associated with
increased risk of cardiovascular disease and impaired functional capacity in the elderly …
increased risk of cardiovascular disease and impaired functional capacity in the elderly …
MicroRNA-221 inhibits autophagy and promotes heart failure by modulating the p27/CDK2/mTOR axis
M Su, J Wang, C Wang, X Wang, W Dong… - Cell Death & …, 2015 - nature.com
MicroRNAs have emerged as crucial regulators of cardiac homeostasis and remodeling in
various cardiovascular diseases. We previously demonstrated that miR-221 regulated …
various cardiovascular diseases. We previously demonstrated that miR-221 regulated …
[HTML][HTML] How cardiomyocyte excitation, calcium release and contraction become altered with age
Cardiovascular disease is the main cause of death globally, accounting for over 17 million
deaths each year. As the incidence of cardiovascular disease rises markedly with age, the …
deaths each year. As the incidence of cardiovascular disease rises markedly with age, the …
Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function
Y Zhang, SL Mi, N Hu, TA Doser, A Sun, J Ge… - Free Radical Biology and …, 2014 - Elsevier
Cardiac aging is associated with compromised myocardial function and morphology
although the underlying mechanism remains elusive. Aldehyde dehydrogenase 2 (ALDH2) …
although the underlying mechanism remains elusive. Aldehyde dehydrogenase 2 (ALDH2) …
Aldehyde dehydrogenase 2 ameliorates doxorubicin-induced myocardial dysfunction through detoxification of 4-HNE and suppression of autophagy
Mitochondrial aldehyde dehydrogenase (ALDH2) protects against cardiac injury via
reducing production of 4-hydroxynonenal (4-HNE) and ROS. This study was designed to …
reducing production of 4-hydroxynonenal (4-HNE) and ROS. This study was designed to …