Maladaptive plasticity in tinnitus—triggers, mechanisms and treatment

SE Shore, LE Roberts, B Langguth - Nature Reviews Neurology, 2016 - nature.com
Tinnitus is a phantom auditory sensation that reduces quality of life for millions of people
worldwide, and for which there is no medical cure. Most cases of tinnitus are associated with …

Predictive coding and stochastic resonance as fundamental principles of auditory phantom perception

A Schilling, W Sedley, R Gerum, C Metzner, K Tziridis… - Brain, 2023 - academic.oup.com
Mechanistic insight is achieved only when experiments are employed to test formal or
computational models. Furthermore, in analogy to lesion studies, phantom perception may …

What's the buzz? The neuroscience and the treatment of tinnitus

A Henton, T Tzounopoulos - Physiological reviews, 2021 - journals.physiology.org
Tinnitus is a pervasive public health issue that affects∼ 15% of the United States population.
Similar estimates have also been shown on a global scale, with similar prevalence found in …

[HTML][HTML] Mechanisms of noise-induced tinnitus: insights from cellular studies

SE Shore, C Wu - Neuron, 2019 - cell.com
Tinnitus, sound perception in the absence of physical stimuli, occurs in 15% of the
population and is the top-reported disability for soldiers after combat. Noise overexposure is …

Auditory-somatosensory bimodal stimulation desynchronizes brain circuitry to reduce tinnitus in guinea pigs and humans

KL Marks, DT Martel, C Wu, GJ Basura… - Science Translational …, 2018 - science.org
The dorsal cochlear nucleus is the first site of multisensory convergence in mammalian
auditory pathways. Principal output neurons, the fusiform cells, integrate auditory nerve …

[HTML][HTML] Tinnitus: does gain explain?

W Sedley - Neuroscience, 2019 - Elsevier
Many, or most, tinnitus models rely on increased central gain in the auditory pathway as all
or part of the explanation, in that central auditory neurones deprived of their usual sensory …

Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models

W Wang, LS Zhang, AK Zinsmaier, G Patterson… - PLoS …, 2019 - journals.plos.org
Hearing loss is a major risk factor for tinnitus, hyperacusis, and central auditory processing
disorder. Although recent studies indicate that hearing loss causes neuroinflammation in the …

Therapeutic approaches to the treatment of tinnitus

B Langguth, AB Elgoyhen… - Annual review of …, 2019 - annualreviews.org
Tinnitus is a highly prevalent condition that is associated with hearing loss in most cases. In
the absence of external stimuli, phantom perceptions of sounds emerge from alterations in …

Neural signatures of auditory hypersensitivity following acoustic trauma

M McGill, AE Hight, YL Watanabe, A Parthasarathy… - Elife, 2022 - elifesciences.org
Neurons in sensory cortex exhibit a remarkable capacity to maintain stable firing rates
despite large fluctuations in afferent activity levels. However, sudden peripheral …

Evidence that hidden hearing loss underlies amplitude modulation encoding deficits in individuals with and without tinnitus

BT Paul, IC Bruce, LE Roberts - Hearing research, 2017 - Elsevier
Damage to auditory nerve fibers that expresses with suprathreshold sounds but is hidden
from the audiogram has been proposed to underlie deficits in temporal coding ability …