Chagas disease, leishmaniasis and schistosomiasis are neglected diseases (NDs) and are
a considerable global challenge. Despite the huge number of people infected, NDs do not …

Peroxisomes of organisms belonging to the protist group Kinetoplastea, which include
trypanosomatid parasites of the genera Trypanosoma and Leishmania, are unique in …

The human pathogenic trypanosomatid species collectively called the “TriTryp parasites”–
Trypanosoma brucei, Trypanosoma cruzi and Leishmania spp.–have complex life cycles …

The use of indigenous or remote popular knowledge to identify new drugs against diseases
or infections is a well-known approach in medicine. The inhabitants of coastal regions are …

The development of drugs that can inactivate disease-causing cells (eg cancer cells or
parasites) without causing collateral damage to healthy or to host cells is complicated by the …

In the past decade, scientific advances in network pharmacology have laid the foundations
for a polypharmacological approach to discover new drugs for complex diseases. There is …

To survive in a very competitive environment, marine macroalgae had to evolve defense
strategies, resulting in an enormous diversity of compounds from different metabolic …

Representatives of all major lineages of eukaryotes contain peroxisomes with similar
morphology and mode of biogenesis, indicating a monophyletic origin of the organelles …

In Trypanosoma cruzi, the causal agent of Chagas disease, the first seven steps of glycolysis
are compartmentalized in glycosomes, which are authentic but specialized peroxisomes …

The molecular repertoire of Trypanosoma cruzi effects its virulence and impacts the clinical
course of the resulting Chagas disease. This study aimed to determine the mechanism …