Diabetes insipidus (DI) is a disorder characterized by excretion of large amounts of
hypotonic urine. Central DI results from a deficiency of the hormone arginine vasopressin …

Intracellular proteins continuously turn over by degradation and synthesis in all organ
tissues. Owing to its irreversible nature, protein degradation is a highly selective process to …

Aquaporins (AQPs) are a family of highly selective transmembrane channels that mainly
transport water across the cell and some facilitate low-molecular-weight solutes. Eight AQPs …

Dietary potassium (K+) supplementation is associated with a lowering effect in blood
pressure (BP), but not all studies agree. Here, we examined the effects of short-and long …

Ensuring the proper amount of water inside the body is essential for survival. One of the key
factors in the maintenance of body water balance is water reabsorption in the collecting …

The kidneys, by equilibrating the outputs to the inputs, are essential for maintaining the
constant volume, pH, and electrolyte composition of the internal milieu. Inability to do so …

Diabetic macroangiopathy–a specific form of accelerated atherosclerosis–is characterized
by intra-plaque new vessel formation due to excessive/abnormal neovasculogenesis and …

Diabetes insipidus (DI) is a disorder characterised by the excretion of large amounts of
hypotonic urine, with a prevalence of 1 per 25,000 population. Central DI (CDI), better now …

In mammals, conservation of body water is critical for survival and is dependent on the
kidneys' ability to minimize water loss in the urine during periods of water deprivation. The …

Renal collecting duct principal cells play a key role in controlling body water balance.
Principal cells express the water channels AQP2, AQP3, and AQP4 that mediate renal water …