Optimizing real-world benefit and risk of new psychedelic medications: the need for innovative postmarket surveillance

JC Black, AA Monte, N Dasgupta, JS Jewell… - Nature Mental …, 2024 - nature.com
The encouraging results of late-phase clinical trials investigating psychedelic-assisted
psychotherapy suggests that US Food and Drug Administration approval and subsequent …

The impact of ketamine for treatment of post-traumatic stress disorder: a systematic review with meta-analyses

DJ Sicignano, R Kurschner… - Annals of …, 2024 - journals.sagepub.com
Background: Ketamine has been used in anesthesia, pain management, and major
depressive disorder. It has recently been studied in patients with post-traumatic stress …

[HTML][HTML] Examining the impact of comorbid posttraumatic stress disorder on ketamine's real-world effectiveness in treatment-resistant depression

DE Johnson, NB Rodrigues, S Weisz… - European …, 2025 - Elsevier
Depression with comorbid posttraumatic stress disorder (PTSD) is associated with more
severe symptoms and a reduced response to traditional treatments. Although ketamine …

Rapid and sustained reduction of treatment-resistant PTSD symptoms after intravenous ketamine in a real-world, psychedelic paradigm

HA MacConnel, M Earleywine… - Journal of …, 2024 - journals.sagepub.com
Background: Traditional treatments for post-traumatic stress disorder (PTSD) often show
limited success with high dropout. Ketamine, an N-methyl-D-aspartate antagonist known for …

[LLIBRE][B] EMBARK Psychedelic Therapy for Depression: A New Approach for the Whole Person

B Brennan, A Belser - 2024 - books.google.com
EMBARK Psychedelic Therapy for Depression: A New Approach for the Whole Person
represents a critical step forward in the field of psychedelic therapy. The book is a …

Functional brain changes after alternative pharmacological interventions in posttraumatic stress disorder: A systematic review of clinical trials

S Lotfinia, A Afshar, A Yaseri, M Olff… - Brain and Behavior, 2023 - Wiley Online Library
Background Posttraumatic stress disorder (PTSD) is a complex and heterogeneous mental
health condition that can develop after exposure to a traumatic event. Clinical trials have …

Prefrontal metabolite alterations in individuals with posttraumatic stress disorder: a 7T magnetic resonance spectroscopy study

MA Reid, SE Whiteman, AA Camden… - Chronic …, 2024 - journals.sagepub.com
Background Evidence from animal and human studies suggests glutamatergic dysfunction
in posttraumatic stress disorder (PTSD). The purpose of this study was to investigate …

[HTML][HTML] Combined Effects of Nasal Ketamine and Trauma-Focused Psychotherapy in Treatment-Resistant Post-Traumatic Stress Disorder: A Pilot Case Series

J Rohde, E Hickmann, M Buchmann, G Kronenberg… - Behavioral …, 2024 - mdpi.com
Objective: This pilot case series investigated the feasibility and efficacy of an eight-week
therapy program, combining nasally administered ketamine (0.5 mg/kg) with trauma-focused …

Advances in the management of posttraumatic stress disorder after critical illness: a narrative review

E Asimakopoulou, P Theodosis-Nobelos… - … and Critical Care …, 2024 - journals.lww.com
Illness requiring critical care can lead to the development of posttraumatic stress disorder
(PTSD), a complex mental health condition resulting from exposure to traumatic events. In …

Low dose oral ketamine treatment on post-traumatic stress disorder (PTSD)(OKTOP): An open-label pilot study

BL Quigley, AT Can, M Dutton, CC Gallay, G Forsyth… - medRxiv, 2024 - medrxiv.org
Ketamine is being actively investigated as a rapid-acting treatment for many conditions with
a stress-related psychopathology, including post-traumatic stress disorder (PTSD). The …