Recent developments in synthetic α-glucosidase inhibitors: A comprehensive review with structural and molecular insight
Diabetes mellitus is the prominent metabolic disorder affecting 422 million people around
the globe and cause severe associated problems like kidney disorders, heart and nervous …
the globe and cause severe associated problems like kidney disorders, heart and nervous …
The bioactivity of thiazolidin-4-ones: A short review of the most recent studies
D Mech, A Kurowska, N Trotsko - International Journal of Molecular …, 2021 - mdpi.com
Thiazolidin-4-ones is an important heterocyclic ring system of a pharmacophore and a
privileged scaffold in medicinal chemistry. This review is focused on the latest scientific …
privileged scaffold in medicinal chemistry. This review is focused on the latest scientific …
[HTML][HTML] Synthesis and anti-α-glucosidase activity evaluation of betulinic acid derivatives
XZ Wu, WJ Zhu, L Lu, CM Hu, YY Zheng… - Arabian Journal of …, 2023 - Elsevier
In this article, a series of betulinic acid derivatives (3a∼ 3u, 4a∼ 4e) were synthesized
through a stepwise structure optimization and evaluated for their anti-α-glucosidase …
through a stepwise structure optimization and evaluated for their anti-α-glucosidase …
Novel Bis-Schiff's base derivatives of 4-nitroacetophenone as potent α-glucosidase agents: Design, synthesis and in silico approach
Bis-Schiff's base derivatives of 4-nitroacetophenone (1–18) were synthesized in good yields
by reacting hydrazone of 4-nitroacetophenone with substituted aldehydes and ketones with …
by reacting hydrazone of 4-nitroacetophenone with substituted aldehydes and ketones with …
Synthesis, crystal structure, hirshfeld surface analysis, DFT calculations, anti-diabetic activity and molecular docking studies of (E)-N'-(5-bromo-2-hydroxybenzylidene) …
In this present work, the newly synthesized compound E)-N'-(5-bromo-2-
hydroxybenzylidene) isonicotinohydrazide (2) has been synthesized and characterized by …
hydroxybenzylidene) isonicotinohydrazide (2) has been synthesized and characterized by …
Evaluation of synthetic 2-aryl quinoxaline derivatives as α-amylase, α-glucosidase, acetylcholinesterase, and butyrylcholinesterase inhibitors
Variety of 2-aryl quinoxaline derivatives 1–23 were synthesized in good yields, by reacting
1, 2-phenylenediamine with varyingly substituted phenacyl bromides in the presence of …
1, 2-phenylenediamine with varyingly substituted phenacyl bromides in the presence of …
Syntheses, in vitro α-amylase and α-glucosidase dual inhibitory activities of 4-amino-1, 2, 4-triazole derivatives their molecular docking and kinetic studies
Abstract Thirty-three 4-amino-1, 2, 4-triazole derivatives 1–33 were synthesized by reacting
4-amino-1, 2, 4-triazole with a variety of benzaldehydes. The synthetic molecules were …
4-amino-1, 2, 4-triazole with a variety of benzaldehydes. The synthetic molecules were …
Novel cinnamic acid magnolol derivatives as potent α-glucosidase and α-amylase inhibitors: Synthesis, in vitro and in silico studies
CM Hu, WJ Wang, YN Ye, Y Kang, J Lin, PP Wu… - Bioorganic …, 2021 - Elsevier
In this study, twenty novel cinnamic acid magnolol derivatives were synthesized, and
screened for their anti-hyperglycemic potential. All synthesized compounds exhibited good …
screened for their anti-hyperglycemic potential. All synthesized compounds exhibited good …
Synthesis, in vitro α-amylase inhibitory, and radicals (DPPH & ABTS) scavenging potentials of new N-sulfonohydrazide substituted indazoles
Over-expression of α-amylase enzyme causes hyperglycemia which lead to many
physiological complications including oxidative stress, one of the most commonly associated …
physiological complications including oxidative stress, one of the most commonly associated …
Design, synthesis, spectroscopic characterizations, antidiabetic, in silico and kinetic evaluation of novel curcumin-fused aldohexoses
Abstract Curcumin (bis-α, β-unsaturated β-diketone) plays an important role in the
prevention of numerous diseases, including diabetes. Curcumin, as an enzyme inhibitor …
prevention of numerous diseases, including diabetes. Curcumin, as an enzyme inhibitor …