[HTML][HTML] Reactive oxygen species accelerate de novo acquisition of antibiotic resistance in E. coli

W Qi, MJ Jonker, W de Leeuw, S Brul, BH Ter Kuile - Iscience, 2023 - cell.com
Reactive oxygen species (ROS) produced as a secondary effect of bactericidal antibiotics
are hypothesized to play a role in killing bacteria. If correct, ROS may play a role in …

The effect of the stringent response and oxidative stress response on fitness costs of de novo acquisition of antibiotic resistance

W Qi, MJ Jonker, D Katsavelis, W de Leeuw… - International Journal of …, 2024 - mdpi.com
Resistance evolution during exposure to non-lethal levels of antibiotics is influenced by
various stress responses of bacteria which are known to affect growth rate. Here, we aim to …

UV-C light-activated gallic acid and ultrasound: A novel approach for reducing enteropathogens inoculated in lettuce (Lactuca sativa L.)

CJ Alvarez-Rodríguez, NX Morales-Martínez… - Food Control, 2024 - Elsevier
The effect of UV-C light-activated gallic acid (AGA) alone or combined with ultrasound (US)
on the inactivation of E. coli and S. Typhimurium inoculated in aqueous solution and lettuce …

Oxygen mediated mobilization and co-occurrence of antibiotic resistance in lab-scale bioreactor using metagenomic binning

S Bombaywala, A Bajaj, NA Dafale - World Journal of Microbiology and …, 2024 - Springer
Sub-lethal levels of antibiotic stimulate bacteria to generate reactive oxygen species (ROS)
that promotes emergence and spread of antibiotic resistance mediated by mobile genetic …

Progression of ampC amplification during de novo amoxicillin resistance development in E. coli

L Nong, M Jonker, W de Leeuw, MT Wortel, B Ter Kuile - MBio, 2024 - journals.asm.org
Beta-lactam antibiotics are the most applied antimicrobials in human and veterinarian health
care. Hence, beta-lactam resistance is a major health problem. Gene amplification of AmpC …

[HTML][HTML] Short-Term Warming Induces Cyanobacterial Blooms and Antibiotic Resistance in Freshwater Lake, as Revealed by Metagenomics Analysis

B Manna, E Jay, W Zhang, X Zhou, B Lyu, GM Thomas… - Water, 2024 - mdpi.com
Climate change threatens freshwater ecosystems, potentially intensifying cyanobacterial
blooms and antibiotic resistance. We investigated these risks in Cosseys Reservoir, New …

[HTML][HTML] Adaptive signatures of emerging Salmonella serotypes in response to stressful conditions in the poultry industry

GI Krüger, C Pardo-Esté, J Álvarez, N Pacheco… - LWT, 2025 - Elsevier
Salmonella, a zoonotic pathogen, is commonly transmitted through contaminated animal
products. This bacterium is emerging in poultry production, often exhibiting multidrug …

Role of RelA-synthesized (p) ppGpp and ROS-induced mutagenesis in de novo acquisition of antibiotic resistance in E. coli

W Qi, MJ Jonker, W de Leeuw, S Brul, BH Ter Kuile - Iscience, 2024 - cell.com
The stringent response of bacteria to starvation and stress also fulfills a role in addressing
the threat of antibiotics. Within this stringent response,(p) ppGpp, synthesized by RelA or …

ROS-Induced Stress Promotes Enrichment and Emergence of Antibiotic Resistance in Conventional Activated Sludge Processes

B Manna, X Zhou, N Singhal - bioRxiv, 2024 - biorxiv.org
Abstract Since the Great Oxidation Event 2.4 billion years ago, microorganisms have
evolved sophisticated responses to oxidative stress. These ancient adaptations remain …

ROS-Induced Oxidative Stress Causes Enrichment and Emergence of Antibacterial Resistance in Conventional Activated Sludge Process

B Manna, X Zhou, N Singhal - 2024 - europepmc.org
Conventional activated sludge (CAS) processes represent significant reservoirs of
antibacterial resistance genes (ARGs). However, the mechanisms governing ARG …