Ubiquitous yet unique, lipid droplets are intracellular organelles that are increasingly being
recognized for their versatility beyond energy storage. Advances uncovering the intricacies …

Metabolic homeostasis in mammals is tightly regulated by the complementary actions of
insulin and glucagon. The secretion of these hormones from pancreatic β-cells and α-cells …

Type II diabetes mellitus and its related complications are growing public health problems.
Many natural products present in our diet, including polyphenols, can be used in treating …

In this review, we focus on recent developments in our understanding of nutrient-induced
insulin secretion that challenge a key aspect of the" canonical" model, in which an oxidative …

Diabetes is a complex and multifactorial disease that affects millions of people worldwide,
reducing the quality of life significantly, and results in grave consequences for our health …

We tested the hypothesis that obesity, independent of insulin resistance, is associated with
increased insulin secretion. We compared insulin kinetics before and after glucose ingestion …

Pancreatic β cells secrete insulin in response to glucose elevation to maintain glucose
homeostasis. A complex network of inter-organ communication operates to modulate insulin …

Whole-body glucose homeostasis is coordinated through secretion of glucagon and insulin
from pancreatic islets. When glucose is low, glucagon is released from α-cells to stimulate …

Background Diabetes always involves variable degrees of β-cell demise and malfunction
leading to insufficient insulin secretion. Besides clinical investigations, many research …

We hypothesize that basal hyperinsulinemia is synergistically mediated by an interplay
between increased oxidative stress and excess lipid in the form of reactive oxygen species …