Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics

P Morigny, J Boucher, P Arner, D Langin - Nature Reviews …, 2021 - nature.com
In mammals, the white adipocyte is a cell type that is specialized for storage of energy (in the
form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte …

Beyond appetite regulation: Targeting energy expenditure, fat oxidation, and lean mass preservation for sustainable weight loss

BØ Christoffersen, G Sanchez‐Delgado, LM John… - …, 2022 - Wiley Online Library
New appetite‐regulating antiobesity treatments such as semaglutide and agents under
investigation such as tirzepatide show promise in achieving weight loss of 15% or more …

The sexual dimorphism of human adipose depots

N Boulet, A Briot, J Galitzky, A Bouloumié - Biomedicines, 2022 - mdpi.com
The amount and the distribution of body fat exhibit trajectories that are sex-and human
species-specific and both are determinants for health. The enhanced accumulation of fat in …

Sexual dimorphism in brown adipose tissue activation and white adipose tissue browning

I Gómez-García, J Trepiana… - International Journal of …, 2022 - mdpi.com
The present narrative review gathers the studies reported so far, addressing sex differences
in the effects of cold exposure, feeding pattern and age on brown adipose tissue (BAT) …

[HTML][HTML] Master of disguise: deconvoluting adipose tissue heterogeneity and its impact on metabolic health

RS Dewal, C Wolfrum - Current opinion in genetics & development, 2023 - Elsevier
Adipose tissue in its different forms: white, brown, and beige, while essential in day-to-day
bodily functions, leads to several disorders when present in overabundance, including …

Of mice and men: Pinpointing species differences in adipose tissue biology

E Börgeson, J Boucher, CE Hagberg - Frontiers in Cell and …, 2022 - frontiersin.org
The prevalence of obesity and metabolic diseases continues to rise, which has led to an
increased interest in studying adipose tissue to elucidate underlying disease mechanisms …

Distinct shades of adipocytes control the metabolic roles of adipose tissues: from their origins to their relevance for medical applications

A Ladoux, P Peraldi, B Chignon-Sicard, C Dani - Biomedicines, 2021 - mdpi.com
Adipose tissue resides in specific depots scattered in peripheral or deeper locations all over
the body and it enwraps most of the organs. This tissue is always in a dynamic evolution as it …

Emerging debates and resolutions in brown adipose tissue research

AM Cypess, B Cannon, J Nedergaard, L Kazak… - Cell Metabolism, 2024 - cell.com
Until two decades ago, brown adipose tissue (BAT) was studied primarily as a thermogenic
organ of small rodents in the context of cold adaptation. The discovery of functional human …

Trichostatin A regulates fibro/adipogenic progenitor adipogenesis epigenetically and reduces rotator cuff muscle fatty infiltration

X Liu, M Liu, L Lee, M Davies, Z Wang… - Journal of …, 2021 - Wiley Online Library
Rotator cuff (RC) muscle fatty infiltration (FI) is an important factor that determines the clinical
outcome of patients with RC repair. There is no effective treatment for RC muscle FI at this …

Baicalin promotes the activation of brown and white adipose tissue through AMPK/PGC1α pathway

Y Zhang, Z Zhang, Y Zhang, L Wu, L Gao, R Yao… - European Journal of …, 2022 - Elsevier
Obesity occurs when energy intake overtops energy expenditure. Promoting activation of
brown adipose tissue (BAT) and white adipose tissue (WAT) has been proven a promising …