Osteocytes, the most abundant and long-lived cells in bone, are the master regulators of
bone remodeling. In addition to their functions in endocrine regulation and calcium and …

Osteoarthritis (OA) is a degenerative disease that affects various tissues surrounding joints
such as articular cartilage, subchondral bone, synovial membrane, and ligaments. No …

Abstract Changes in the stiffness of chondrocyte extracellular matrix (ECM) are involved in
the pathological progression of osteoarthritis (OA). However, the downstream responses of …

Osteoarthritis (OA) is characterized by impairment of the load-bearing function of articular
cartilage. OA cartilage matrix undergoes extensive biophysical remodeling characterized by …

The function of articular cartilage as a load-bearing connective tissue is derived primarily
from a balanced interaction between the swelling proteoglycan (PG) matrix and tension …

Articular cartilage is classified as permanent hyaline cartilage and has significant differences
in structure, extracelluar matrix components, gene expression profile, and mechanical …

Osteoarthritis (OA) is characterized by cartilage degeneration and destruction, leading to
joint ankylosis and disability. The major challenge in diagnosing OA at early stage is not …

Osteoarthritis (OA), one of the most common degenerative diseases, is characterized by
progressive degeneration of the articular cartilage and subchondral bone, as well as the …

Background In the last years, several clinical trials have proved the safety and efficacy of
adipose-derived stem/stromal cells (ASC) in contrasting osteoarthritis (OA). Since ASC act …

Sandwiched between articular cartilage and subchondral bone, the calcified cartilage layer
(CCL) takes on both biomechanical and biochemical functions in joint development and …